Skip to content

Neuromodulation and Fatigue

Neuromodulation and Its Effects on Muscle Activity and Fatigue

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05487131
Enrollment
40
Registered
2022-08-04
Start date
2023-06-03
Completion date
2027-12-01
Last updated
2026-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatigue, Healthy Aging

Keywords

Transcutaneous spinal direct current stimulation, TsDCS, Fatigability

Brief summary

In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation. Healthy individuals will participate in one familiarization followed by up to 6 experimental sessions. Fatigability and motor function will be assessed in each test session.

Detailed description

This project will investigate the potential impact of an electrical current of low intensity, and applied non-invasively, on the signals that drive muscle contractions. Individuals will receive distinct types of stimulation that vary depending on the direction on the current (anodal vs cathodal) and placement of the electrodes. These conditions will be compared to a sham stimulation. The test session will be randomized in a double blind fashion, which indicates that neither participants or investigators will know the type of stimulation. Motor function and the muscle electrical activity will be quantified during each test session.

Interventions

BEHAVIORALelectrical stimulation

different types of low-intensity (comfortable) electrical stimulation will be used and applied in distinct locations

Sponsors

University of Oklahoma
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy individuals between 18 and 50 years old

Exclusion criteria

Metal implants or joint replacement. Presence of neuromuscular disease. Skin hypersensitivity.

Design outcomes

Primary

MeasureTime frameDescription
ForceEach session will take approximately 2 hours (total of 4 test sessions)Change in force will be evaluated with a device during each test session
Perception of effortEach session will take approximately 2 hours (total of 4 test sessions)Change in perceived effort will be evaluated with visual analogue scales
Muscle activationEach session will take approximately 2 hours (total of 4 test sessions)Electromyography will be used to quantify muscle activation

Countries

United States

Contacts

CONTACTHugo Pereira, PhD
hugomax@ou.edu405-325-2773
PRINCIPAL_INVESTIGATORHugo Pereira, PhD

University of Oklahoma

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 10, 2026