Molecular Characterization of Gliomas Using a Broad Next Generation Sequencing (NGS)Panel

Molecular Characterization of Gliomas Using a Broad NGS Panel

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05486247

Enrollment

Registered

2022-08-03

Start date

2015-02-04

Completion date

2022-05-01

Last updated

2022-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant Glioma

Keywords

Molecular profile, Mutational status

Brief summary

Gliomas are the most common malignant primary brain tumors with poor prognosis. The genotyping of tumors using NGS platforms enables the identification of genetic alterations that constitute diagnostic, prognostic and predictive biomarkers.Here in, we investigated the molecular profile of 32 tumor samples from 32 patients with high grade gliomas by implementing a broad 80-gene targeted NGS panel while reporting their clinicopathological characteristics and outcomes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Diagnosis of high grade glioma based on tissue biopsy

Design outcomes

Primary

Measure	Time frame	Description
The prevalence of genetic alterations in patients with high grade glioma using a 80 gene NGS panel	April 2019 - December 2021	The prevalence of genetic alterations in patients with high grade glioma using a 80 gene NGS panel

Outcome results