Sleep Disturbance
Conditions
Keywords
circadian, light, cognition, Zeitgeber, personalized, health, sleep, muliti-modal
Brief summary
The main objective of the study is to improve subjective sleep quality using a multimodal intervention with an intervention and a control group. The multimodal intervention aims to improve circadian Zeitgeber strength. This will be achieved by optimizing daily light exposure, sleep, physical activity, and mealtimes.
Detailed description
The study lasts for 14 months and contains 6 visits. After the screening visit at the Centre for Chronobiology, Basel, Switzerland, participants are assigned to either the intervention or the control group which is followed by a 7-day baseline week at home and a co-design meeting to provide instructions to the intervention and the control group. At the occasion of 2 visits (spread over 6 months) at the participants' homes, different measurements will be performed such as saliva collection, questionnaires, cognitive performance tests, light and rest-activity measures. After the last visit at home, participants come for the second blood sample at the study centre. A follow-up visit 6 months after completion of the last data collection will provide qualitative feedback by the participants.
Interventions
BEHAVIORALMultimodal intervention
Participants in the intervention group will receive personalised advice on sleep, light exposure, meal times and physical activity.
BEHAVIORALControl
General sleep advice
Sponsors
Mirjam Münch
University of California
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Masking description
Participants are unaware whether they are in the intervention or the control group
Intervention model description
Randomized Clinical Trial with a control group
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
at least 65 years old women and men * Pittsburgh Sleep Quality Index (PSQI) \> 5 (indicative of sleep problems) * Living at home (including self-serviced retirement apartment)
Exclusion criteria
* Total blindness or VA \< 0.5 * Progressive NCDs (e.g., cancer) * Acute infections (e.g., Covid-19) * Neurodegenerative disease * Psychiatric disease * Sleep disorder (sleep apnea, narcolepsy) * Not German speaking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Subjective sleep quality | 6 months | Pittsburgh Sleep Quality Index (Score \> 5 indicates poor sleep) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sleep timing | 6 months | Derived from Activity Watches |
| Subjective wellbeing | 6 months | Visual Analogue Scales |
| Salivary melatonin concentration | 6 months | Circadian phase marker |
| Pupil size | 6 months | Pupil response to chromatic light stimuli |
| Glucose metabolism | 6 months | HbA1c concentration (blood) |
| Telomere length | 6 months | Age marker |
| Neuropsychological Battery to assess working memory and attention (including n-back, Psychomotor Vigilance Test) | 6 months | Cognitive Function |
Countries
Switzerland
Contacts
PRINCIPAL_INVESTIGATORMirjam Münch, PhD
Research Associate
Outcome results
None listed