Inflammatory Bowel Diseases
Conditions
Keywords
modified bowel preparation method, inflammatory bowel disease, risk factors, quality of bowel preparation
Brief summary
The purpose of this study is to investigate the effect of modified colonoscopy bowel preparation method compared with traditional method on bowel cleansing effect, colonoscopy examination effect and clinical condition of inflammatory bowel disease patients. Risk factors affecting the quality of bowel preparation will also be studied.
Interventions
Take asol as total enteral nutrition, and take polyethylene glycols and glycerin enema as bowel preparations
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis: inflammatory bowel disease (IBD) patients, including ulcerative colitis (UC) and Crohn's disease (CD), have colonic involvement. * Patients and/or family members can understand the study protocol and are willing to participate in the study and provide informed consent in writing.
Exclusion criteria
* The diagnosis is not definite. * Toxic megacolon, gastrointestinal perforation or other acute abdominal diseases; Patients with gastrointestinal bleeding with unstable vital signs. * Patients after colon surgery. * Serious underlying diseases, organ failure, or inability to cooperate with colonoscopy for other reasons. * Patients can not cooperate with the use of polyethylene glycol or glycerin enema. * Patients or family members cannot understand the conditions and objectives of this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The quality of bowel preparation evaluated by endoscopists during colonoscopy. | During colonoscopy examination | The quality of bowel preparation will be evaluated with the Boston bowel preparation scale (BBPS), including the total Boston score (range 0-9, score 8-9 means excellent, 7 means good, less than 7 means bad) and score of per bowel segment (maximum 3). |
| Number of Participants with increased Disease activity after colonoscopy. | Within 7 days after colonoscopy | Disease activity will be assessed using C-reactive protein (CRP) measurement, the modified Mayo score in ulcerative colitis and the Crohn's Disease Activity Index score in Crohn's Disease. If the result after colonoscopy was higher than before, the participant may be considered with increased disease activity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tolerance score of participants after bowel preparation. | After bowel preparation and before colonoscopy | Tolerance score is defined range 0-10 (0 means totally intolerant, 10 means feel really good). |
| Number of Participants who has a record of outpatient or emergency treatment due to aggravation of disease after colonoscopy. | Within 30 days after colonoscopy | Number of Participants who has a record of outpatient or emergency treatment due to aggravation of disease within 30 days after colonoscopy. |
| Number of Participants hospitalized because of aggravation of disease after colonoscopy. | Within 30 days after colonoscopy | Number of Participants who is hospitalized because of aggravation of disease within 30 days after colonoscopy. |
Countries
China
Contacts
Primary ContactHui Xu, MD
Backup ContactHong Yang, MD
Outcome results
None listed