Colorectal Tumors, Lidocaine
Conditions
Keywords
Radical resection of colorectal tumor, lidocaine, stress, immunity, vascular tumor regeneration, inflammation, micrometastasis
Brief summary
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Surgical resection is the main treatment option for colorectal cancer patients. Surgery may enhance or accelerate tumor recurrence and metastasis. Multiple factors in the tumor microenvironment play important roles in tumor recurrence and metastasis, and modulating the tumor microenvironment can inhibit disease progression. Lidocaine has been found to inhibit tumor growth in animal experiments.
Detailed description
Lidocaine was applied in the operation of colorectal tumor patients, and the effect on the postoperative microenvironment and micrometastasis of the patients was observed by detecting the stress, immunity, vascular tumor regeneration, inflammation, etc. of the patients.
Interventions
DRUGAdminister 1.5 mg/kg intravenously to the patient before induction of anesthesia, and continue to infuse 1.5 mg/kg/h during the operation until the end of the operation
Administer 1.5 mg/kg lidocaine
Sponsors
Affiliated Hospital of Nantong University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* colorectal tumor patients
Exclusion criteria
* Weight \<45kg and \>100kg * Sensitivity or hypersensitivity to lidocaine * Second or third degree heart block * Severe heart failure (ejection fraction \< 20%) * History of active rhythm disorder * Acute severe liver and kidney injury * History of uncontrolled seizures * History of acute porphyria.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the concentration of tumor micrometastasis markers were determined by ELISA | 3 days after surgery | the concentration of tumor micrometastasis markers such as CK20 was determined by ELISA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the concentration of stress hormones were determined by ELISA | 3 days after surgery | the concentration of EPI and NE were determined by ELISA |
| the concentration of inflammatory factor were determined by ELISA | 3 days after surgery | the concentration of IL-6,IL-8,TNF-α were determined by ELISA |
| the concentration of angiogenesis factors were determined by ELISA | 3 days after surgery | the concentration of VEGF was determined by ELISA |
| the concentration of immune indexes were determined by ELISA | 3 days after surgery | the concentration of B lymphocytes, T lymphocytes, NK cells, macrophages were determined by ELISA |
Countries
China
Outcome results
None listed