Breast Cancer
Conditions
Keywords
Breast Cancer, Radiation Therapy, Brass Mesh, Bolus, Skin Dose
Brief summary
The hypothesis is that the daily use of brass mesh bolus achieves a comparable dose to every-other-day use of Superflab bolus (current standard of care) in chest wall post-mastectomy patients treated with rotational 6 MV photon delivery.
Detailed description
Intervention: During a standard-of-care 15 fraction radiotherapy treatment, a brass mesh bolus will be used for a single fraction. Small in-vivo dosimeters will be used for three treatment fractions to measure and compare skin doses for quantification purposes. Comparator: Superflab and no bolus applied as per the treating physician's practice, typically on alternate days. The intervention and comparator tools are to be utilized on each participant. Primary outcome 1. To determine the skin dose under brass mesh bolus and compare it with the skin dose under Superflab bolus (current standard of care). 2. To determine the number of fractions for which brass mesh bolus should be used to achieve an acceptable skin dose.
Interventions
DEVICEBrass Mesh Bolus
During a standard-of-care 15 fraction radiotherapy treatment, a brass mesh bolus will be used for a single fraction. Small in-vivo dosimeters will be used for three treatment fractions to measure and compare skin doses for quantification purposes.
Sponsors
Hannah Dahn
Nova Scotia Cancer Centre
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
This is a single-site study designed to generate data quantifying the skin dose under brass mesh bolus.
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Women undergoing rotational chest wall radiotherapy following mastectomy for breast cancer treatment who would utilize Superflab bolus on some, but not all, days of radiotherapy treatment.
Exclusion criteria
Patients who require daily bolus due to skin involvement or other high-risk features requiring a high skin dose will not be included.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skin Dose Enhancement Under Brass Mesh Bolus | through study completion, an average of 1 year | During days one, two, and three of radiation therapy, patients on this study utilize no-bolus, 5-mm thick Superflab bolus, and brass mesh bolus, respectively. Each day, nine in-vivo dosimeters (OSLDs) will be placed on patient skin to sample the skin dose in cGy. As a result, for each patient on this study, skin dose enhancement of brass mesh compared with no-bolus can be related to that of Superflab bolus. At the end of the study, the average and range of skin dose enhancement under brass mesh bolus for a sample size of twenty patients will be reported. |
Countries
Canada
Contacts
Primary ContactHannah Dahn, MD
Outcome results
None listed