RBC Transfusions
Conditions
Keywords
RBC transfusions, storage age, meta-analysis
Brief summary
The recent four RCTs evaluating effects of RBC storage age on morbidity and mortality found no statistically significant adverse effects of longer stored RBC compared to shorter storage ages. Unfortunately, none of these RCTs had sufficient numbers of subjects receiving RBC at either storage age extreme to identify consequences of RBC transfusion at these limits. To better investigate effects of RBC storage age on clinical outcomes, this study will perform secondary meta-analyses of merged common patient data elements -individual patient data (IPD) meta-analysis (IPDMA) - from the nearly 33,000 subjects enrolled in the four RCTs.
Interventions
OTHERno intervention
This is an observational retrospective study (meta-analysis)
Sponsors
University of Minnesota
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Received at least one RBC transfusion * \>=18 years of age
Exclusion criteria
* N/A
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | 28 days after transfusion | Estimate the effect of transfused RBC storage-age on time to all-cause mortality |
| Hospital length of stay | after transfusion through 28 days | Estimate the effect of transfused RBC storage-age on hospital stay |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality at 28 days for long-storage | 28 days after transfusion | all-cause mortality at 28 days comparing subjects who received (one or more) RBC unit ≥ 35 days vs. no unit \> 35 days |
| 28 day mortality for short-storage | 28 days after transfusion | 28 day mortality for subjects who received (one or more) RBC unit ≤ 7 days vs. no unit ≤ 7 days |
Countries
United States
Outcome results
None listed