Evaluation of HRCT Patterns in Systemic Sclerosis-associated Interstitial Lung Disease

Unsupervised Clustering Evaluation of HRCT Patterns in Systemic Sclerosis-associated Interstitial Lung Disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05482607

Acronym

LUNGSCLEROCT

Enrollment

100

Registered

2022-08-01

Start date

2023-01-01

Completion date

2025-10-01

Last updated

2024-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Interstitial Lung Disease, Systemic Sclerosis

Brief summary

Systemic sclerosis (SSc) is a heterogeneous systemic autoimmune disease with distinct prognosis according to patients. Interstitial lung disease (ILD) concerns almost 50 % of SSc patients and represents the main cause of mortality. SSc-ILD is variable: from limited forms (with asymptomatic patients) to extensive lesions. Disease course in SSc-ILD is also highly variable: patients can experience stable disease, slow or fast progression. Investigators performed unsupervised clustering analysis to classify SSc-ILD according to elementary radiological lesions on HRCT scan.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with systemic sclerosis according to 2013 ACR/EULAR criteria * Patients with interstitial lung disease on HRCT chest

Exclusion criteria

* Patients with an alternative diagnosis of SSc-associated ILD (silicosis, sarcoidosis, lung cancer or other significant lung abnormalities)

Design outcomes

Primary

Measure	Time frame	Description
HRCT scan variables	baseline (J0)	HRCT scan variables included in hierarchical agglomerative clustering (HAC) analysis

Countries

France

Contacts

Primary ContactPaul DECKER, MD

p.decker@chru-nancy.fr+33383157240

Outcome results