Vancomycin Dosage
Conditions
Brief summary
All patients treated with vancomycin hospitalized outside of ICU in Brest University Hospital from 1rst january 2019 to 1rst january 2021 will be screened for inclusion. Vancomycin dosage, age, weight and serum creatinin will be recorded. Seven pharmacokinetic models' predictive performance will be evaluated on this database. Using the best model, we will perform Monte-Carlo simulation to elaborate dosing nomograms and develop dosing recommandations of continuous infusion of vancomycin.
Detailed description
Monte Carlo simulations will be performed according to varying creatinin clearance values and weight, for both the loading dose and the maintenance dose.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* All patients hospitalized in Brest University Hospital, * treated with vancomycin and receiving pharmacological monitoring * between 1rst January 2019 and 1rst January 2021
Exclusion criteria
* Missing data on vancomycin administration * Refusal to be included in this study * Hospitalisation in ICU
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Imprecision in Predictive performance of seven pharmacokinetic models | September 2021 | The model with the lesser imprecision reported on the Observed vs Predicted Concentrations Graph will be selected |
| Bias in Predictive performance of seven pharmacokinetic models | September 2021 | The model with the lesser bias reported on the Observed vs Predicted Concentrations Graph will be selected |
Countries
France
Outcome results
None listed