Abortion, Blood Loss, Hysterectomy, Maternal Transmission, Placenta Accreta Spectrum, Repeat Cesarean Section
Conditions
Brief summary
This study is a prospective cohort study, led by Prof. Zhao Yangyu, from the Department of Gynecology & Obstetrics, Peking University Third Hospital.
Detailed description
Cesarean section, myomectomy and other surgeries for uterus are likely to cause scars in different parts of the uterus. During the subsequent pregnancy, the incidence rate of cesarean scar pregnancy, placenta previa, placenta increta and the risk of termination of the first and mid-trimester pregnancy is likely to increase. Cesarean scar pregnancy is regarded as a risk factor of uterine rupture in the third trimester of pregnancy or delivery period, which severely affects the maternal and perinatal health and safety. This study is planning to prospectively include pregnant women aged 20-49 years from Peking University Third Hospital. All women with diagnosis on cesarean scar pregnancy was included prior to 14 wks of gestation. We divided the women into three different groups: type I, type II and type III according to characteristics in gestation sac,uterine scar, bladder, the latter with potentially worse outcomes in term of maternal morbidity and mortality. Data including demographics, medical history, reproductive history, prenatal health care, gestational complications, and pregnancy and birth outcomes will be collected via electronic data capture system.
Interventions
None listed
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* Female aged ≥ 20 years * Female with cesarean scar pregnancy * Less than 14 gestational weeks * Planning to receive prenatal healthcare and delivery service at the study hospital
Exclusion criteria
* Inability to provide informed consent * Women with mental disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of perinatal death | 42 days postpartum | perinatal death |
| Incidence of spontaneous abortion | delivery | spontaneous abortion |
| Incidence of stillbirth | delivery | stillbirth |
| Incidence of blood loss | delivery | blood loss |
| Incidence of postpartum hemorrhage | delivery | postpartum hemorrhage |
| Incidence of maternal transfusion | delivery | maternal transfusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The rate of repeated cesarean delivery | At delivery | Cesarean rate is defined as the number of cesarean delivery divided by the number of live births. |
| Maternal death | At 24-28 weeks | Deaths during pregnancy or less than 42 days after termination of pregnancy |
Contacts
Primary ContactYangyu Zhao, MD
Outcome results
None listed