Chills
Conditions
Keywords
spinal anesthesia, vaginal hysterectomy, shivering
Brief summary
comparison of Dexmedetomidine And Ketamine For Control Of Shivering In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia.
Detailed description
In this study the participants aim to Compare Dexmedetomidine And Ketamine For Control Of Shivering In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia regarding efficacy, hamemodynamic stability, outcomes and adverse effects.
Interventions
DRUGDexmedetomidine
I/V bolus of dexmedetomidine 0.1 mg/kg as a 20 ml solution, followed by 0.04mg/kg/hr infusion
DRUGKetamine
0.2 mg/kg iv of ketamine diluted to 20 ml followed by 0.1 mg/kg/hr infusion
Sponsors
Hamdard University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
the drugs will be prepared by anesthesiologist who will not be the part of the study and these drugs will be injected by another anesthesiologist who will be blinded to the drugs and will be participating into the study.
Intervention model description
Patients will be randomly assigned to either group Dexmedetomidine (receiving I/V bolus of dexmedetomidine 0.1 mg/kg as a 20 ml solution, followed by 0.04mg/kg/hr infusion till surgery completion) OR group Ketamine (receiving 0.2 mg/kg iv of ketamine diluted to 20 ml followed by 0.1 mg/kg/hr infusion till surgery completion) through sequentially numbered opaque sealed envelope. Anesthesiologist and patients both will be blinded to the administered drug in two groups. Either of the drugs will be injected after giving spinal anesthesia and confirmation of achievement of desired level of block. In the recovery room Shivering grade, and vitals of patients will be evaluated every 15 minutes interval after giving the drug till 1hour postoperatively. 1st reading taken 15minutes after giving the drug will be labelled as Zero time.
Eligibility
Sex/Gender
FEMALE
Age
45 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients of age 45-55 years requiring vaginal hysterectomy 2. American Society of Anesthesiology (ASA) of Grade I-II
Exclusion criteria
1. Patients unwilling or non-cooperative for spinal anesthesia 2. Patients with uncontrolled hypertension, vascular or coronary disease, 3. patients with increased intraocular or intracranial pressure 4. Patients with known bleeding and psychiatric disorders 5. Patients taking anti platelets drugs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Shivering grade | Shivering grade of patients will be evaluated every 15 minutes interval after giving the drug till 1hour postoperatively | Shivering of patients will be grouped into five grades; Grade 0: lack of shivering, Grade I: slight shivering (inconsiderable yet apparent peripheral vasoconstriction), Grade II: medium level shivering (muscular activity in one muscle group only), Grade III: severe shivering (muscular activity in more than one muscle group without generalized shivering), Grade IV: generalized shivering. |
Contacts
Primary ContactNida Shahid, MBBS, FCPS
Outcome results
None listed