Mechanically Ventilated Patients
Conditions
Brief summary
Aspiration of respiratory secretions is a frequently needed procedure in intubated patients . Cough is an important defence mechanism to clear mucus from the upper and lower airways . The presence of an endotracheal tube impairs the ability to cough.There are a number of techniques to mobilise sputum and optimise airway clearance for invasively ventilated patients. Endotracheal suctioning is the most common intervention used to remove retained airway secretions from within the endotracheal tube, trachea and upper airways .Mechanical insufflation-exsufflation (MI-E) aids sputum clearance from upper and lower airways. This technique augments inspiratory and expiratory flows to improve sputum mobilisation, through the application of rapidly alternating positive and negative pressure, which approximates a normal cough
Detailed description
Critically ill patients under invasive ventilation are at risk for sputum retention . Aspiration of respiratory secretions is a frequently needed procedure in intubated patients . Cough is an important defence mechanism to clear mucus from the upper and lower airways . The presence of an endotracheal tube impairs the ability to cough. This prevents the enhancement of cough velocity . Furthermore, critically ill patients frequently have an impaired or no cough reflex due to depressed levels of consciousness, sedation, muscle weakness or muscle paralysis. Sputum retention, resulting from an inability to cough effectively, is one cause of extubation failure which in turn is associated with increased mortality. There are a number of techniques to mobilise sputum and optimise airway clearance for invasively ventilated patients. Endotracheal suctioning is the most common intervention used to remove retained airway secretions from within the endotracheal tube, trachea and upper airways . Endotracheal suctioning though is not effective for clearing secretions from the lower airways . New technologies and advanced methods have been developed to increase the effectiveness of mucus clearance in patients with acute respiratory failure, including mechanical insufflation-exsufflation devices. This technique has been described as an effective aid for mucus clearance in patients with chronic muscle weakness or neuromuscular disease. Mechanical insufflation-exsufflation (MI-E) aids sputum clearance from upper and lower airways. This technique augments inspiratory and expiratory flows to improve sputum mobilisation, through the application of rapidly alternating positive and negative pressure, which approximates a normal cough .
Interventions
Group 1 allocated to conventional tracheal suctioning,all patiemts will be followed up until discharge from ICU or death Tracheal suctioning will be performed following the American Association for Respiratory Care recommendations.
Group 2 will be allocated to mechanical insufflation-exsufflation which will be performed with the which will be applied 5 times in 5cough cycles in automatic mode, with insufflation and exsufflation pressures of + 40/-40 cmH2O, respectively. The duration of each phase was 3 s, without pause. Hyperoxygenation (100% O2) will be performed for 1 min before applying each technique and a 20 s interval will be allowed between repetitions.
Sponsors
Study design
Eligibility
Inclusion criteria
Adult patients of both sexes on mechanical ventilation in RICU with any respiratory disease Mechanically ventilated Patients without facial trauma Mechanically ventilated Patients hemodynamically stable
Exclusion criteria
Patients diagnosed with barotrauma Patients diagnosed with pneumothorax History of bullous emphysema Known susceptibility to pneumothorax or pneumo-mediastinum
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assess effects of MIE on blood pressur | 1 year | Blood pressure measuered in mmHg |
| Assess effects of MIE on Oxygen saturation | 1 year | — |
| Assess effects of MIE on heart rate | 1 year | Heart rate measured by beats per minute |
| Assess effects of MIE on Volume of Secretions | 1 year | Volume of Secretions measured in ml |
| Assess effects of MIE on respiratory rate | 1 year | Respiratory rate measured by breaths per minute |
| Assess effects of MIE on tidal volume | 1 year | Tidal volume measured in cubic centimeter |
| Assess effects of MIE on minute ventilation | 1 year | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assess safety of Mechanical insufflation-exsufflation | 1 year | assess safety according to number of complications e.g (hypotension, arrythmias, oxygen desaturaion, pneumothorax) and number of participants with complications |
Other
| Measure | Time frame | Description |
|---|---|---|
| Compare the effects and safety of MIE versus Endotracheal Suctioning | 1 year | Comparison accoring to number of complications with each procedure |