Stroke
Conditions
Brief summary
Stroke is currently the most common disabling disease, which often leads to impairment of sensory, motor, speech and psychological functions, resulting in a reduced quality of life for patients. Therefore, post-stroke functional rehabilitation, especially the rehabilitation of physical function and psychological condition, is particularly important for patients to rejoin society. Acupuncture can promote the functional recovery of patients and facilitate the rehabilitation of limb function, thus improving the quality of survival of post-stroke patients. Neurotrophic factors are diverse, most of which are mainly derived from neuronal cells in the central nervous system and are involved in a variety of neurological functions such as cell growth, differentiation and plasticity, thus promoting recovery of multiple functions after stroke. Many studies have found that different interventions affect the prognosis of stroke patients differently, e.g., long-term acupuncture increases serum levels of brain-derived neurotrophic factor in stroke patients and also has better outcomes than controls in post-stroke neurological recovery and the development of post-stroke psychiatric disorders. This study investigated the effects of different therapeutic measures on patients' functional recovery and neurotrophic factors by setting up a controlled and blinded trial design, which could not only provide clinical evidence for the effectiveness of relevant therapeutic measures, but also verify the clinical value of certain neurotrophic factors (e.g., predicting outcome, assessing condition, and preventing adverse events).
Interventions
PROCEDUREacupuncture
Manual acupuncture or electro-acupuncture by experienced acupuncturists for patients
BEHAVIORALcomputerized cognitive training system
One-on-one cognitive training by an experienced cognitive therapist, combined with an existing computerized cognitive training system
BEHAVIORALaerobic exercise
Patients are trained by experienced physical therapists with the help of elastic bands and physical therapy devices
BEHAVIORALtranditional cognitive training
One-on-one cognitive training with an experienced cognitive therapist, combined with traditional cognitive training methods (e.g., balls, cards, counting, daily conversation, etc.)
OTHERConventional treatment
Treatment of underlying disease and stroke according to guidelines, as well as necessary care and rehabilitation
Sponsors
Chongqing Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Symptom recognition to admission ≤ 72 hours * Clear imaging evidence * Diagnosis of spontaneous cerebral hemorrhage by an immobilized physician according to relevant guidelines; pre-onset mRS score ≤ 1
Exclusion criteria
* This onset was caused by traumatic and violent factors * History of previous intracranial surgery * Previous cerebrovascular accident * Previous speech disorders and limb movement disorders * Participation in other trials in the last three months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| modified rankin scale | Change of the score of modified rankin scale from Baseline at 1 week after onset of disease | The mrs (modified rankin scale) is a scale used to assess the patient's ability to care for himself/herself, which is composed of independent walking ability, self-perceived symptoms, and ability to control bowel and urine.Assessment results range from 0-6 points，a higher score means a worse ending |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mini-mental State Examination | Change of the score of modified rankin scale from Baseline at 1 week, 2 weeks, 1 month, 2 months, 3 months after onset of disease | The MMSE (Mini-mental State Examination) is a scale that assesses patients' cognition in terms of calculation, orientation, memory, and recall on a scale of 0-30, which is combined with the patient's level of education to yield results for different levels of cognitive impairment. |
Countries
China
Contacts
Primary ContactLingcong Li, M.S. in Medicine
Outcome results
None listed