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Reproductive Outcomes After a Previous Episode of Tubal Ectopic Pregnancy in Patients Managed Expectantly and Surgically

Evaluation of Reproductive Outcomes After Expectant or Surgical Management of a Previous Episode of Tubal Ectopic Pregnancy

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05479786
Enrollment
312
Registered
2022-07-29
Start date
2012-01-01
Completion date
2020-12-31
Last updated
2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ectopic Pregnancy

Keywords

Ectopic pregnancy, Expectant management, Pregnancy outcome, Salpingectomy, Salpingostomy

Brief summary

Although ectopic pregnancy was considered a leading cause of first-trimester maternal mortalities, current technological improvements allowed early diagnosis and opened a door for applying less invasive approaches. A tubal pregnancy could be managed either expectantly, medically, or surgically. The expectant management of ectopic pregnancy relies on the fact that a considerable proportion of ectopic gestations terminate by spontaneous tubal abortion. This approach is usually kept for stable cases with a small gestational sac and low beta-human chorionic gonadotropin (beta-HCG) serum levels. For hemodynamically unstable patients, higher levels of beta-HCG, and larger gestational sacs, surgery is often considered as the treatment of choice (16). Considering this background, the study aims to analyze the subsequent natural reproductive outcomes of patients that had a previous tubal ectopic pregnancy and were managed either expectantly or surgically. Moreover, it amis to determine the factors that could influence the fertility potential of these patients in each treatment group.

Interventions

Follow-up with beta-HCG dosages and transvaginal ultrasound scans

PROCEDURESalpingectomy

Removal of the affected Fallopian tube by laparoscopy

PROCEDURESalpingostomy

Removal of the ectopic pregnancy from the Fallopian tube, without removing the whole Fallopian tube, by laparoscopy

Sponsors

University of Debrecen
CollaboratorOTHER
Damascus University
CollaboratorOTHER
University of Palermo
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No

Inclusion criteria

* Women with one episode of tubal ectopic pregnancy, treated by expectant management, salpingectomy, or salpingostomy; * For patients treated surgically, only patients with at least one patent Fallopian tube confirmed via postoperative hysterosalpingography were included in the analysis.

Exclusion criteria

* Pregnancies of unknown location * Other types of ectopic pregnancy * Pelvic inflammatory disease * Pelvic adhesions * Intrauterine pathologies * Pregnancies obtained after assisted-reproductive technologies (ART)

Design outcomes

Primary

MeasureTime frameDescription
Clinical pregnancy rateWithin one year after the previous episode of tubal ectopic pregnancyPresence of a gestational sac under ultrasonography

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026