Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.

Effect of Ascorbic Acid as a Final Flush on Post-operative Pain After Single Visit Root Canal Treatment for Patients With Symptomatic Irreversible Pulpits Related to Mandibular Molars: Randomized Controlled Trial.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05478044

Enrollment

Registered

2022-07-28

Start date

2022-08-31

Completion date

2023-08-31

Last updated

2022-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Pain

Brief summary

The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.

Interventions

DRUGAscorbic acid

Ascorbic acid IV ampoules (20%).

OTHERsaline

saline (0.9%)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients above 18 years old and to 60. * Male or female. * Patients seeking root canal treatment. * mandibular molar teeth with symptomatic irreversible pulpits with preoperative acute or moderate pain with hot and cold stimulation with normal periapical radiographic appearance . * healthy patient (ASA I,II). * Patient who can understand NRS and sign informed consent.

Exclusion criteria

* Medically compromised patients having significant systemic disorders. (ASA III or IV). * History of intolerance to NSAIDS. * External root resorption. * Internal root resorption. * Vertical root fracture. * Periapical lesion. * Pregnancy. * Use of ibuprofen in the last 12 hour. * Bleeding disorder. * Long term corticosteroid use. * Mobility Grade II or III. * Pocket depth more than 5mm. * Previous root canal therapy. * Non-restorability. * TMJ problems, bruxism, clenching or traumatic occlusion. * Inability to perceive the given instructions.

Design outcomes

Primary

Measure	Time frame
Pain intensity measured by numerical rating scale where 0= no pain, 1-3= mild pain, 4-6= moderate pain and 7-10= severe pain.	up to 48 hours after root canal treatment.

Secondary

Measure	Time frame
If there are analgesics taken by the patient after root canal treatment and that will be measured by a questionnaire.	up to 48 hours.

Contacts

Primary ContactKariman Amin Ismaiel, B.D.S faculty of dentistry

kariman.ameen@dentistry.cu.edu.eg+20 1013665586

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026