Alzheimer Disease
Conditions
Keywords
Anxiety, Alzheimer, Dementia, Agitation, Irritability, Music Intervention, Music Medicine, Music Improvisation
Brief summary
Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients. As a direct sound-based approach, CDIM does not rely on autobiographical memory and may have wider applicability and generalizability. We wish to examine if CDIM decreases anxiety in 15 cognitively healthy individuals and 15 Alzheimer Disease patients with anxiety (AD-A).
Detailed description
The goal of this study is to identify the neural mechanisms of induced calmness through live clinically designed improvisatory music (CDIM) in cognitively healthy individuals and persons with Alzheimer's dementia suffering from agitation. This study is novel as most music interventions for dementia use familiar music and the underlying neural mechanism of calmness induced by music is not well known. We plan to investigate changes in 3 major large-scale brain networks using functional magnetic resonance imaging (fMRI). The major questions we plan to answer are as follows: 1. How does improvisatory music change the connectivity within brain emotion related networks in neurotypical individuals? 2. Does improvisatory music induce a state of calmness in individuals with Alzheimer's dementia and how? Based on objective evidence provided by this study we can justify further usage of music for patients with Alzheimer's, in particular, in the form of improvisation.
Interventions
BEHAVIORALClinically Designed Improvisatory Music
Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients.
Sponsors
Northwestern University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
15 individuals with Alzheimer Disease (AD) and 15 cognitively healthy individuals.
Eligibility
Sex/Gender
ALL
Age
55 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
1. Cognitively healthy individuals Cognitively healthy control participants evaluated through the Northwestern Mesulam Center. BAI \> 8.
Exclusion criteria
hearing loss 2. Individuals with mild to moderate Alzheimer's disease This group will similarly be recruited through the Mesulam Center. All individuals recruited by the research Core at the center are well characterized tests standardized across all NIH funded Alzheimer Centers across the nation. Individuals with mild to moderate neurocognitive disorder due to AD will have an MMSE greater than \>15 and Clinical Dementia Rating (CDR) between 0.5 and 2.. They will also have a history of neurocognitive-related agitation/anxiety, and a Beck Anxiety Index (BAI) or Rating for Anxiety in Dementia (RAID) greater than 8, suggestive of at least a mild level of anxiety.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Neuropsychiatric Inventory (NPI) [NPI-1: pre-intervention; NPI-2: post-intervention] | Through study completion (3 years) | Change in NPI (NPI-2 minus NPI-1) |
| Change in Beck Anxiety Inventory [BAI-1: pre-intervention; BAI-2: post-intervention] | Through study completion (3 years) | Change in BAI (BAI-2 minus BAI-1) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Systolic Blood Pressure [SBP-1: pre-intervention; SBP-2: post-intervention] | Through study completion (3 years) | Change in SBP (SBP-2 minus SBP-1) |
| Change in Heart rate [HR-1: pre-intervention; HR-2: post-intervention] | Through study completion (3 years) | Change in HR (HR-2 minus HR-1) |
| Change Respiratory Rate [RR-1: pre-intervention; RR-2: post-intervention] | Through study completion (3 years) | Change in RR (RR-2 minus RR-1) |
| Change in Skin conductance [SC-1: pre-intervention; SC-2: post-intervention] | Through study completion (3 years) | Change in SC (SC-2 minus SC-1) |
| Change in Resting state functional connectivity MRI | Through study completion (3 years) | Functional Connectivity within three resting state networks: Change in Default Network (DN), Change in Salience Network (SN), and Change in Reward Network (RN). |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORBorna Bonakdarpour, MD, FAAN
Northwestern Mesulam Center for Cognitive Neurology and Alzheimer Disease
Outcome results
None listed