Cognitive Impairment, Motor Disorders, Parkinson Disease
Conditions
Brief summary
Neuromuscular dysfunction is common in older adults and even more pronounced in neurodegenerative diseases. In Parkinson's disease (PD), a complex set of factors often prevents effective performance of activities of daily living that require intact and simultaneous performance of motor and cognitive tasks. In the current study we aim at employing the Mobile Brain/Body Imaging approach (MoBI) to gain further insides of neuromuscular biomarkers revealing the decrements of older adults with an early PD. The cross-sectional study will be evaluated through the multifactorial mixed-measure design.
Interventions
DIAGNOSTIC_TESTExtensive motor-cognitive testing protocol
Screening of their functional performance while monitoring brain and muscle activity
Sponsors
Technische Universität Berlin
University of Geneva, Switzerland
University of Trieste
University Maribor
Science and Research Centre Koper
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria for the healthy older participants will be: * no diagnosis of cognitive or movement disorder, * score \> 7 for the Short Physical Performance Battery (SPPB), * living independently in the community, * age range between 55 and 70 years, * no color blindness. Inclusion criteria for the early-stage PD patients: * diagnosed according to the last MDS criteria (2015), * duration of the disease less than 5 years, * positive DATSCAN, * diagnosed akinetic-rigid or mixed phenotype, * score of 1 or maximally 2 on the Hoehn and Yahr scale (Hoehn & Yahr, 1967), * MoCA score ≥ 24 points, * score \> 7 for the SPPB, * age range between 50 and 75 years, * no color blindness * living independently in the community.
Exclusion criteria
* advanced stages of PD (Hoehn and Yahr score \> 2) * any acute or chronic diseases, especially of the peripheral and central nervous system, heart failure, respiratory failure, severe osteoarthritis, and major psychiatric illness such as depression * MoCA score \< 24 points, * severe disabling tremor, * recurrent falls, * impaired vision that is not corrected with e.g., glasses, * low SPPB score
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| dual-task costs while walking | Day 1 | Test for dual-task costs associated with the concurrent execution of overground walking and a secondary cognitive task |
| dual-task costs while standing | Day 1 | Test for dual-task costs associated with the concurrent execution of semi-tandem stance and a secondary cognitive task |
| dual-task costs while execution of isometric task | Day 1 | Test for dual-task costs associated with the concurrent execution of isometric contraction and a secondary cognitive task |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) | Day 1 | Assessment of various aspects of PD including motor and non-motor experience of daily living and the related complications |
Countries
Slovenia
Contacts
Primary ContactUros Marusic, PhD
Outcome results
None listed