Cardiovascular Diseases, Diabetes Mellitus, Gestational Diabetes Mellitus in Pregnancy, Hyperglycemia, Hypertension, Maternal Obesity During Childbirth, Overnutrition, Pregnancy
Conditions
Keywords
Hyperglycemia, Pregnancy, Overnutrition, Maternal Obesity, Diabetes Mellitus, Cardiovascular Diseases, Gestational Diabetes Mellitus, Hypertension, Young Adulthood
Brief summary
The prevalence of diabetes mellitus (DM) and cardiovascular disease (CVD) escalate remarkably worldwide and obesity becomes an epidemic disease. This study is interested in how the model of Developmental Origin of Health and Disease (DOHaD) influence individual's health status as they reach young adulthood. Since the mothers from HAPO study have not been subjected to antenatal treatment on the various degree of maternal hyperglycaemia in pregnancy, this would be an unique cohort that allows determination of the effect of various degree of maternal hyperglycaemia below the level of overt DM, on children's cardiometabolic risk in Chinese population.
Detailed description
The investigators recruited 1760 Chinese pregnant women between 2000 and 2005. The HAPO study investigated whether any adverse outcome was associated with mild degree of GDM. All mothers underwent a 75-gram OGTT at 24-32 weeks gestation, but clinicians were blinded to the results as long as the fasting PG was ≤ 5.8 mmol/L & 2-hour PG ≤ 11.1 mmol/L. The maternal serum C-peptide and HbA1c, cord serum C-peptide and early neonatal PG, pregnancy outcome and the neonatal anthropometric parameters are available for future study. This is so far the largest cohort in a Chinese population who has been investigated for glycaemia during pregnancy, but with OGTT results remained undisclosed to subjects and clinicians. This unique cohort can allow us to study the effect of in-utero hyperglycemia on the cardiometabolic risks at childhood, adolescence and adulthood. Eligible subjects are all mother-child pairs participating in the original HAPO study. Children born preterm before 37 weeks of gestation, non-Chinese and whose mother's OGTT result were unblinded during pregnancy will be excluded.The family (the child and the mother) will be invited for a third follow-up assessment.
Interventions
None listed
Sponsors
Chinese University of Hong Kong
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Mother-child pairs who had been assessed in HAPO follow-up study at either 7 years or 11-14 years old
Exclusion criteria
* Children born preterm before 37 weeks of gestation * Non-Chinese * Mothers' OGTT results were unblinded during pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of DM in the young adult offspring | At a time around 18 years of age | Study specimens would be collected to identify the rate of DM in young adult offspring. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of impaired glucose regulation, obesity and adiposity, hypertension and various insulin indices | At a time around 18 years of age | Study specimens would be collected to identify the percentage of impaired glucose regulation, obesity and adiposity, hypertension and various insulin indices in young adult offspring. |
Countries
Hong Kong
Contacts
Primary ContactChi Chiu Wang
Outcome results
None listed