Maternal Obesity, Pregnancy Complications
Conditions
Keywords
gasdermin-D, pannexin-1, placenta, omental tissue, fat tissue, maternal obesity, inflammation, oxidative stress, biochemistry, ELISA
Brief summary
One -third of fertile women around the world are overweight or obese. This means increasing risk for both the mother and the child. Fat tissue is a factor in gestational DM development and the increase in material inflammation and oxidative stress. According to new knowledge, it is an important need to examine molecules that are not handled in new and human research in these mechanisms in fat and placenta tissues in obesity. For this purpose, the examination of the expression of gasdermin-D and pannex-1 proteins, which are shown to be produced in the cells of both tissues, is worth investigating in human fat tissue and placenta. Gasdermins and pannexins are proteins intersecting by interacting in cellular functions. Gasdermins cause piroptosis, a type of litic proinflammatory cell death. Pannexin-1 plays in various cellular functions, including inflammation. These are examined in a small number of in vitro studies in material fat tissue and placenta, and the design of this study in people whose applications are applied is original in humans. The status of the expressions of the gasdermin-D and pannexin-1 proteins, which will be examined for the first time in obese pregnant women's fat and placental tissues, are the subject of this research with each other and their relationship with other maternal and neonatal data.
Interventions
DIAGNOSTIC_TESTBiomarker measurement of pannexin-1 and gasdermin-D
These biomarkers were measured in the placental and adipose tissues of the participants.
Sponsors
Haseki Training and Research Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Being in the 20-35 age range * Term pregnancy (37-41 weeks) * Healthy pregnancy follow-up * Planned cesarean section * Having no complication in cesarean delivery * Being a placenta with front or rear walls
Exclusion criteria
* Intrauterine surgical procedure * Presence of prenatal placental structural disorder * Multiple pregnancies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prediction of macrosomy | 7 months | Prediction of macrosomy will be assesed by meaningfull increases of studied biomarkers Gasdermin-D and Pannexin-1 |
Countries
Turkey (Türkiye)
Outcome results
None listed