Colorectal Cancer Metastatic, Surgical Procedure, Unspecified
Conditions
Keywords
colorectal cancer, synchronous colorectal liver metastases, simultaneous resection, postoperative outcomes
Brief summary
The use of a simultaneous resection in patients with synchronous colorectal liver metastases has increased over the past decades. However, it remains unclear when a simultaneous resection is beneficial and when it should be avoided. The objective of this retrospective study is therefore to compare the outcomes of a simultaneous resection for synchronous colorectal liver metastases in different settings, and to assess which factors are independently associated with unfavorable outcomes.
Interventions
PROCEDUREMajor liver resection
Major liver resection (3 or more contiguous segments)
PROCEDURETechnically major liver resection
Minor liver resection (\<3 contiguous segments) in the posterosuperior segments (segment 1,4a,7,8)
Sponsors
University of Amsterdam
Universita di Verona
Umberto I Mauriziano Hospital Turin
IRCCS Azienda Ospedaliero-Universitaria di Bologna
IRCCS San Raffaele
University Hospital Padua
Riuniti Hospital Polytechnic University of Marche Ancona
Clinica Universidad de Navarra Pamplona
Groeninge Hospital Kortrijk
Oslo University Hospital and Institute of Medicine
The Queen Elizabeth Hospital
Antoine Béclère Hospital Paris
Moscow Clinical Research Centre
University Hospital of Girona Dr. Josep Trueta
University Hospital Southampton NHS Foundation Trust
Università Cattolica del Sacro Cuore-IRCCS Rome
Fondazione Poliambulanza Istituto Ospedaliero
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Elective minimally invasive or open simultaneous resection of colorectal cancer and synchronous colorectal liver metastases
Exclusion criteria
* (Partially) robotic-assisted or thoracoscopic procedures * First stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) * Patients that underwent major concurrent procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major complications | 30 days postoperatively | Severe complications (Clavien-Dindo grade 3a or higher) related to the surgical procedure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay | 30 days postoperatively | The length of hospital stay for the surgical procedure |
| R0 resection margin | 30 days postoperatively | Proportion of patients in whom a microscopically radical resection of both the primary colorectal carcinoma and the liver metastases was performed. |
| Intraoperative blood loss | During the surgical procedure | Intraoperative blood loss in milliliters |
| Operative time | During the surgical procedure | Operative time in minutes |
| Overall complications | 30 days postoperatively | Overall complications related to the surgical procedure |
| Mortality | 90 days postoperatively | Postoperative mortality |
| Red blood cell transfusion | During the surgical procedure | Intraoperative red blood cell transfusion |
| Intraoperative incidents | During the surgical procedure | Intraoperative unfavourable incidents |
| Conversion to open surgery | During the surgical procedure | Intra-operative conversion to an open or hand-assisted procedure in the minimally invasive group |
Countries
Italy
Outcome results
None listed