Cognitive Impairment, Postoperative Delirium
Conditions
Keywords
postoperative delirium, abdominal surgery, malondialdehyde, S100B protein, Tau protein, pNF-H, Bispectral Index, anesthesia depth, general anesthesia
Brief summary
The study targets postoperative delirium in patients undergoing major abdominal surgery, with the aim to evaluate the functional baseline and proteomics implicated in pathogenesis, prevention strategies (such as anesthesia depth monitoring) and incidence in certain population groups.
Interventions
DEVICEBIS monitoring
The depth of anesthesia will be monitored using Bispectral Index values.
Sponsors
Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* ASA risk I-III; * patients undergoing complex digestive surgery, such as esophagectomy, total gastrectomy, hemicolectomy, cephalic duodenopancreatectomy, hepatic resection.
Exclusion criteria
* the impossibility of obtaining the patient's consent/his decisional incapacity; * patients who underwent neurosurgery for cerebrospinal lesions / cardiac surgery under cardiopulmonary bypass; * prediagnosed senile/vascular/mixed dementia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prediction model for postoperative delirium (POD) in major abdominal surgery | 3-4 years | Developing an accesible algorithm to anticipate the occurence of postoperative delirium, based on functional baseline and proteomics, in adult patients subjected to major abdominal surgical interventions. This includes investigating a correlation between a set of risk factors, a panel of biomarkers and the occurrence of postoperative delirium in the enrolled patients, respectively. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anesthesia depth monitoring and the incidence of postoperative delirium | 0-4 days postoperatively | Assessing the influence of BIS monitoring during general anesthesia on the prevalence of postoperative delirium |
| Postoperative delirium incidence in surgical patients in the Intensive Care Unit (ICU) setting | during ICU hospitalization | — |
| Postoperative delirium incidence in surgical patients - subgroup - communism survivors | during ICU hospitalization | — |
| Postoperative delirium incidence in surgical patients - subgroup - patients with no relatives/visitors | during ICU hospitalization | — |
Other
| Measure | Time frame | Description |
|---|---|---|
| The influence of POD on length of stay (LOS), unplanned ICU re-admission, cognitive decline and mortality | during patient hospitalization | Evaluating the possibility of a correlation between the occurence of POD and prolonged hospitalization, a prerequisite for ICU re-admittance or further cognitive deterioration / mortality. |
Countries
Romania
Contacts
Primary ContactMara Mihaescu, PhD student
Backup ContactDaniela Ionescu, MD,PhD
Outcome results
None listed