Pediatric Cataract
Conditions
Keywords
congenital cataract, traumatic cataract, complicated cataract, ocular structure parameters, surgical/vision recovery timing and strategies, postoperative adverse effects, psychologic and cognitive function, artificial intelligence
Brief summary
This retrospective-prospective bidirectional cohort study aims to observe ocular parameter changes, different surgical/vision recovery strategies and postoperative adverse effects among young children with cataract. The influence on psychology and cognitive function will be taken into consideration as well.
Detailed description
Pediatric cataract, one of the leading causes of childhood blindness globally, is complex and of great difficulty in treatment. Pediatric patients with cataract (congenital, traumatic or complicated) are enrolled. In this study, investigators will compare ocular parameter changes, different surgical/vision timing or recovery strategies and adverse effects among young children （age \< 18 yo）before and after cataract surgery. The influence on psychology and cognitive function will be taken into consideration as well. The whole blood samples of participants and parents are collected and retained in our biobank for gene sequencing, hoping to explore the genetic factors in association with pathogenesis. For children received cataract surgery, samples of partial anterior capsular tissue and 1 ml aqueous humor were collected during operation for further analysis. Multimodal artificial intelligence analyses are performed to establish accurate diagnosis/treatment scheme and disease prediction model.
Interventions
None listed
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* aged \< 18 yo at the 1st visit unilateral or bilateral cataract agree to participant in this study and sign the informed consent
Exclusion criteria
* adults
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence changes of postoperative complications | Baseline and through study completion, an average of 1 year | Incidence of postoperative complications, such as glaucoma-related adverse, myopic shift, strabismus and anisometropia and so on |
| Best-corrected visual acuity changes | Baseline and through study completion, an average of 1 year | Best-corrected visual acuity changes are measured by visual acuity charts (Teller/Lea symbol/ETDRS chart) every 1 year at scheduled time |
| Intraocular pressure changes | Baseline and through study completion, an average of 1 year | Intraocular pressures are measured by NCT machine |
| Refractive power changes | Baseline and through study completion, an average of 1 year | Refractive power are measured at baseline and every visit at least every 1 year |
| Ocular biological measurements changes | Baseline and through study completion, an average of 1 year | Ocular biological measurements including axial length, corneal keratometry, anterior chamber angle/depth, corneal endothelial cell number and appearance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Other factors changes | Baseline and through study completion, an average of 1 year | Sleep, depression, cognitive function are measured by questionnaires. Self-Rating Scale of Sleep: minimum value-1 point, maximum value-50, and higher scores mean worse outcome. Hamilton Depression Scale: \<7 points-normal, and higher scores mean worse outcome. Loewenstein Cognitive Assessment: for every question, minimum 1 point, and maximum 4 points. Higher scores mean worse outcomes. |
| BMI changes | Baseline and through study completion, an average of 1 year | BMI is measured by technicians in every visit |
| Blood pressure changes | Baseline and through study completion, an average of 1 year | Diastolic and systolic blood pressure are measured by technicians in every visit |
| Stereopsis changes | Baseline and through study completion, an average of 1 year | Stereopsis is measured by Randot Stereotest |
| Optical coherence tomography (OCT) changes | Baseline and through study completion, an average of 1 year | Retinal thickness is measured and analyzed by OCT |
Countries
China
Contacts
Primary ContactZhenzhen Liu, PhD
Outcome results
None listed