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Real-Life Study in Diabetic Macular Edema

Real-World Outcomes of Anti-VEGF Treatment for Diabetic Macular Edema in Turkey: A Multicenter Retrospective Study, MARMASIA Study Group

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05472376
Enrollment
854
Registered
2022-07-25
Start date
2020-11-29
Completion date
2022-06-15
Last updated
2022-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Macular Edema

Brief summary

The goal of this study is to evaluate the real-world outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in diabetic macular edema (DME) patients.

Detailed description

The study included patients who were being observed in the retina departments of 8 tertiary hospitals in the Northern Marmara Region of Turkey (Istanbul's Asian Side, Kocaeli, and Sakarya). The records of DME patients treated with an anti-VEGF agent between January 2015 and December 2018 were reviewed.

Interventions

Retrospective study

Sponsors

Kocaeli University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Inclusion criteria

* Diabetic macular edema treated with intravitreal anti-VEGF injection * Having at least 4 or more annual examination visits

Exclusion criteria

* Phacoemulsification surgery in the last 1 month * PRFK / grid / focal / micropulse in the last 4 months * Previous intraocular surgery (excluding PPV and phacoemulsification)

Design outcomes

Primary

MeasureTime frameDescription
Visit and Intravitreal Injection NumbersFirst yearThe primary outcomes were changes in best-corrected visual acuity and central macular thickness in the first year and frequency of visits and intravitreal anti-VEGF injections.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026