REM Sleep Behavior Disorder
Conditions
Keywords
iRBD
Brief summary
REM sleep behavior disorder is a parasomnia that reflects the presence of alpha-synucleinopathy in the brain and is highly predictive of eventual phenoconversion to Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy over the course of years to decades. Neuroplastic adaptations in the brain during the prodromal stage of disease are thought to mask the expression of motor and non-motor signs and may substantially delay diagnosis during a potentially critical time window. This study will examine the state and progression (over 30 to 36 months) of neuroplastic changes in the excitability of the motor and prefrontal cortex (using transcranial magnetic stimulation), the structural and functional connectivity of the brain (using highfield, 7T, magnetic resonance imaging), and the relationship of these changes to the expression of motor and neuropsychological signs, in a cohort of individuals with REM sleep behavior disorder and matched controls.
Interventions
OTHERNatural progression over time
Each subject will attend eight testing sessions (MRI scanning, two TMS-motor test visits, two TMS-prefrontal test visits, motor assessments, neuropsychological testing, and overnight sleep testing (polysomnography - PSG).
Sponsors
University of Minnesota
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
for the iRBD Group: * Diagnosis of polysomnogram-confirmed isolated iRBD. * Able to ambulate independently without the use of an assistive device (e.g., cane) for 50 meters. * Age: 21-75 years. Inclusion Criteria For Control Subject Group: * Age: 21-75 years. * Able to ambulate independently without the use of an assistive device (e.g., cane or walker for 50 meters.
Exclusion criteria
for iRBD group: * Dementia diagnosis and/or a University of California Brief Assessment of Capacity to Consent (UBACC) score and MacCAT-CR score indicating impaired capacity to consent. * History of musculoskeletal disorders that significant affect movement of lower or upper limbs as determined at the time of enrollment. * Other significant neurological disorders that may affect participation or performance in the study. * Anti-depressant associated RBD. Individuals will be excluded if their dream enactment emerged or clearly worsened after initiating an antidepressant medication. * Meet criteria for overt Parkinson's disease, dementia with Lewy bodies, Multiple Systems Atrophy, Alzheimer's disease, or other neurodegenerative disorder, or other known cause of RBD (e.g., narcolepsy and drug induced RBD). * Untreated sleep-disordered breathing * History of musculoskeletal disorders that significantly affect movement of lower or upper limbs as determined at the time of enrollment. * Pregnant women * Additional
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Boston Naming Test | 30 to 36 months from baseline | Higher score means less impairment |
| Change in Trail Making Test A | 30 to 36 months from baseline | Higher score means more impairment |
| Change in Trail Making Test B | 30 to 36 months from baseline | Higher score means more impairment |
| Change in HVLT | 30 to 36 months from baseline | Higher score means less impairment |
| Change in WMS-3 Spatial Span | 30 to 36 months from baseline | Higher score means less impairment |
| MRI Progression over 30 to 36 months | 30 to 36 months from baseline | Yes/No whether a change was observed from baseline |
| Change in Beck Depression Inventory score | 30 to 36 months from baseline | Higher score means more impairment |
| Change in Mattis Dementia Rating Scale | 30 to 36 months from baseline | Higher score means less impairment |
| Change in Rey Complex Figure | 30 to 36 months from baseline | Higher score means less impairment |
| Change in WAIS-IV Matrix Reasoning | 30 to 36 months from baseline | Higher score means less impairment |
| Change in Stroop Color | 30 to 36 months from baseline | Higher score means less impairment |
| Change in Stroop Word | 30 to 36 months from baseline | Higher score means less impairment |
| Change in Stroop Color Word | 30 to 36 months from baseline | Higher score means less impairment |
| Change in Wisconsin Card Sorting Test | 30 to 36 months from baseline | Higher score means more impairment for subsections "# persev errors" and FMS; less impairment for subsections "# categories" and conceptualization |
| Change in D-KEFS | 30 to 36 months from baseline | Higher score means less impairment |
| Change in BVMT-R | 30 to 36 months from baseline | Higher score means less impairment |
Countries
United States
Contacts
CONTACTMadison Wylie, MS
PRINCIPAL_INVESTIGATORColum MacKinnon, Ph.D
University of Minnesota
Outcome results
None listed