TCA 15% Chemical Peel for Improvement in Hand Lentigines

Use of TCA 15% + 3% Glycolic Acid Chemical Peel for Improvement in Hand Lentigines

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05471947

Enrollment

Registered

2022-07-25

Start date

2023-03-15

Completion date

2024-12-01

Last updated

2025-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lentigo, Photoaging

Keywords

Photoaging, Chemical Peel, Lentigines, Hand Rejuvenation

Brief summary

This study will evaluate the efficacy of the a 15% trichloroacetic acid + 3% glycolic acid peel combination for treatment of lentigines on the hands. This peel combination is sold over the counter. Patients will receive 3 treatments (spaced 4 weeks).

Detailed description

This clinical investigation is a prospective study consisting of a screening visit, 3 treatment visits, and 1 follow-up visit. Baseline and post-treatment photos will be graded and compared. A total of 20 patients will be recruited. Following informed consent and screening, subjects' dorsal hands will be photographed. Patients will receive 3 treatments with the 15% TCA + 3% glycolic acid peel every 4-6 weeks on the dorsal hands. Post-treatment, patients will be instructed to apply Aquaphor to the treated area twice daily for 5 days. Patients' hands will be photographed at each visit. Four to six weeks after their final treatment, subjects will return for photography.

Interventions

DRUG15% Trichloroacetic acid + 3% glycolic acid

Treatment of the hand with an over-the-counter chemical peel containing 15% trichloroacetic acid + 3% glycolic acid

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

22 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age \>21 * No laser, chemical peel, neuromodulator, filler treatment to the hands in \>3 months * At least 5 lentigines on each hand

Exclusion criteria

* Pregnancy * Breastfeeding * Allergy to trichloroacetic acid * Allergy to glycolic acid * Open wounds on treatment area (hands) * Active inflammatory disease on treatment area such as atopic dermatitis, psoriasis, dermatomyositis

Design outcomes

Primary

Measure	Time frame	Description
Improvement in hand lentigines on a 5-point scale	4-6 weeks after last treatment	Photos will be graded on a 5 point scale (0=no change, 1=1-25% change, 2=26-50% change, 3=51-75% change, 4=76-100% change)

Secondary

Measure	Time frame	Description
Improvement in hand lentigines using the Global Aesthetic Improvement Scale	4-6 weeks after last treatment	The GAIS is a validated scale assessing overall change after aesthetic procedures

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026