Placenta Accreta
Conditions
Brief summary
The patients will be divided into 2 groups: Group (A) - Study group: Cases managed by lower segment resection with ligation of the anterior division of the internal iliac artery Group (B) - Control group: Cases managed by lower segment resection without ligation of the anterior division of the internal iliac artery The following operative details will be recorded: * Estimation of total blood loss * Pre and 24-h post-operative hemoglobin (g/dl). * The need for blood transfusion and its amount intra or postoperative will be recorded * Operative time and postoperative hospital stay will be recorded. * Close post-operative monitoring of the patients' vital signs, drain output, and urine output * Presence or absence of intraoperative complications; bladder, ureteric, bowel, or vascular injuries will be recorded. * Monitoring for postoperative morbidities
Detailed description
The patients will be divided into 2 groups: Group (A) - Study group: Cases managed by uterine lower segment resection with ligation of the anterior division of the internal iliac artery (4 cm distal to the bifurcation of the common iliac artery). Group (B) - Control group: Cases managed by uterine lower segment resection without ligation of the anterior division of the internal iliac artery. In both groups, bilateral uterine artery ligation at 2 levels will be done; bilateral ligation at a level below the lower most placental part, followed by bilateral uterine artery ligation at the level of the hysterotomy incision. The following operative details will be recorded: * Estimation of total blood loss * Pre and 24-h post-operative hemoglobin (g/dl). * The need for blood transfusion and its amount intra or post-operative will be recorded * Operative time and postoperative hospital stay will be recorded. * Close post-operative monitoring of the patients' vital signs, drain output, and urine output * Presence or absence of intraoperative complications; bladder, ureteric, bowel, or vascular injuries will be recorded. * Monitoring for postoperative morbidities
Interventions
PROCEDUREStudy group: lower segment resection with ligation of the anterior division of the internal iliac artery
Cases managed by uterine lower segment resection with ligation ((suturing)) of the anterior division of the internal iliac artery (4 cm distal to the bifurcation of the common iliac artery); in addition to the bilateral uterine artery ligation at 2 levels; bilateral ligation at a level below the lower most placental part followed by bilateral uterine artery ligation at the level of the hysterotomy incision.
PROCEDUREControl group: lower segment resection without ligation of the anterior division of the internal iliac artery
Cases managed by uterine lower segment resection without ligation of the anterior division of the internal iliac artery. (i.e., only bilateral ligation at a level below the lower most placental part followed by bilateral uterine artery ligation at the level of the hysterotomy incision).
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: 20-40 years old. * Pregnancy of singleton living fetus. * Previous one or more cesarean sections. * Gestational age: \> 36 weeks. * Elective termination of pregnancy. * Cases not requiring preoperative blood transfusion. * Cases with focal area of placental adherence or invasion leaving sufficient healthy myometrial tissue for uterine repair and preservation. * The following ultrasound markers such as loss of clear retroplacental translucency, myometrial thinning, abnormal lacunae, irregular bladder wall, utero-vesical hypervascularity.
Exclusion criteria
* Multifetal pregnancy. * More than four previous sections. * Emergency termination of pregnancy due to antepartum hemorrhage, placental separation or rupture uterus. * Intrauterine fetal death. * Women with history of any medical disorder with pregnancy eg. Gestational diabetes and hypertension. * Premature rupture of membranes. * Cases misdiagnosed as placenta accreta by ultrasound preoperatively, and spontaneous full placental separation occurred intraoperative. will be excluded before randomization * Cases with PAS with total invasion involving all placental lobules. * Cases who will be managed by cesarean hysterectomy due to uncontrolled intraoperative bleeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of blood loss intra-operative | during operation | Amount of blood loss intra-operative |
| Amount of blood loss 24 hours post-operative | 24 hours post-operative | Amount of blood loss 24 hours post-operative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Operative time | during operation | duration of the surgery |
| Number of blood units transfused | within 24 hours after surgery | Number of blood units transfused within 24 hours after surgery |
Countries
Egypt
Outcome results
None listed