Ear Diseases, Hearing Disorders, Otorhinolaryngologic Diseases, Tinnitus
Conditions
Keywords
Nap modulated tinnitus, Sleep modulated tinnitus, sleep apneas
Brief summary
The proposed research is a non-interventional study made to evaluate different measurements on 1 group of participants, before and after taking a nap, aiming to potentially guide future investigations on nap-modulated tinnitus to better understand this phenomenon. The main hypothesis is that sleep apneas could be correlated with an increase of tinnitus intensity.
Detailed description
1. \- Background : Tinnitus is a really important concern due to its high prevalence (10% world population) and its deteriorating effects on life quality. Subjective tinnitus still remains a scientific enigma because of its partial elucidation. The limited knowledge on its causes can be partially attributed to its intrinsic heterogeneity. In questionnaires previous to this study, 34% of participants showed a characteristic symptomatology of interactions between tinnitus and their sleep : they feel their tinnitus at its maximum intensity after sleeping periods (nap and sleep). In most cases they describe a frank rise of the intensity, compared in scientific papers to the exploding head syndrome. Therefore this study aims to determine what are the main physiopathological processes correlated to the rises of tinnitus 2. \- Objectives : Estimate the correlations between tinnitus intensity changes (before and after the nap) and the number of sleep apneas. Secondary measurements are described in the outcome field.
Interventions
OTHERNapping
Patients are already equipped with electrodes when they pass a test battery before the nap to evaluate mechanisms potentially correlated with tinnitus modulation. Then they do a nap, the nap is stopped when several periods of sleep are seen on EEG (electroencephalogram). Then the test battery is done backwards to evaluate the same measures.
Sponsors
Fondation Lopez-Loreta
Service du sommeil de l'hôpital de l'Hôtel-Dieu
Robin Guillard EIRL
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Affiliated participant or beneficiary of a social security scheme * Acceptation of protocol and signature of non-opposition * Frankly nap-modulated tinnitus (increase of intensity after napping) * Tinnitus maskable by white noise equal or inferior to 85 dB
Exclusion criteria
* Persons under juridic protection (guardianship or safeguard of justice) * Clear cognitive incapacity (not understanding/nor apprehend the study tasks) * Pregnancy or breast feeding * Epilepsia * Non-equilibrated chronic metabolic pathology * Non-equilibrated psychiatric pathology * Difficulty in napping * Important hyperacusis * Meniere's disease, fast fluctuating tinnitus (seconds or minutes), pulsatile tinnitus * Any patient benefiting of a tinnitus treatment that was modified in the last 3 months * Superficial wound, open or partially not cauterized
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Average change in minimum masking level of tinnitus (measured in dB) | Average from 6 naps of 5 minutes sleep each over 2 days of participation | Minimum masking level is measured with a wideband 20hz-12kHz noise before and after each nap of 5 minutes sleep. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between muscular tension (Electromyogram + Trigger Points) and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Using electromyogram on suprahyoid and masseter muscles, trigger points are done searching for muscle nodes |
| Correlation between Middle ear mobility (Impedancemetry) and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Using a multi-frequency impedancemeter |
| Correlation between tubal function (Tubomanometry) and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Using tubomanometer, the eustachian tube is controled (what pressure through the noise is needed) |
| Correlation between articular dysfunction (Physiotherapy Tests) and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Using cervical rotation test + adapted spurling test + jaw mobility in antepulsion and diduction |
| Correlation between change in averaged electroencephalogram alpha band power and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Difference of alpha band power in the EEG signal averaged on the whole scalp between the resting state of 90s before the 5 minutes nap and the one after. |
| Correlation between sleep apnea index (number of apnea/hyponea events per hour) and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Sleep apnea index is measured during naps using plethysmography and using air flow measurements through cannulas. |
| Correlation between change in averaged electroencephalogram theta band power and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Difference of theta band power in the EEG signal averaged on the whole scalp between the resting state of 90s before the 5 minutes nap and the one after. |
| Correlation between change in averaged electroencephalogram beta band power and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Difference of beta band power in the EEG signal averaged on the whole scalp between the resting state of 90s before the 5 minutes nap and the one after. |
| Correlation between change in averaged electroencephalogram gamma band power and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Difference of gamma band power in the EEG signal averaged on the whole scalp between the resting state of 90s before the 5 minutes nap and the one after. |
| Correlation coefficient between audition thresholds (Audiogram) values and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Using an audiometer |
| Correlation between change in averaged electroencephalogram delta band power and change in minimum masking level of tinnitus (measured in dB) | 6 naps of 5 minutes sleep each over 2 days of participation | Difference of delta band power in the EEG signal averaged on the whole scalp between the resting state of 90s before the 5 minutes nap and the one after. |
Countries
France
Outcome results
None listed