COPD
Conditions
Keywords
early COPD, spirometry, lung health
Brief summary
This is a multi-center, prospective, cohort study in early COPD patients. This study aims to elucidate the lung function decline and its association with smoking and other risk factors. Other biomarkers and image markers from chest CT scan are also analyzed to investigate the lung function in early COPD patients.
Interventions
BEHAVIORALsmoking
Smoking history and spirometry are used to define groups
Sponsors
Chinese Academy of Medical Sciences
Ting YANG
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Gender: male or female 2. Age: 35-75 years old 3. post-bronchodilator spirometry: FEV1/FVC \< 0.8 and FEV1%pred ≥80%
Exclusion criteria
1. Other diseases may affect lung function, like lung cancer, bronchiectasis, interstitial lung disease or chest surgery. 2. BMI \> 35 kg/m2 3. Dementia or other severe neurological disease 4. Pregnancy 5. Conditions that contraindicated lung function test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lung function decline in Pre-COPD and Mild-COPD patients | 2 years | FEV1 decline in Pre-COPD and Mild-COPD patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lung function decline in smokers with Pre-COPD and Mild-COPD | 2 years | FEV1 decline in smokers with Pre-COPD and Mild-COPD |
| Lung function decline in non-smokers with Pre-COPD and Mild-COPD | 2 years | FEV1 decline in non-smokers with Pre-COPD and Mild-COPD |
Other
| Measure | Time frame | Description |
|---|---|---|
| Lung function decline and biomarkers in Pre-COPD and Mild-COPD patients | 2 years | Association between FEV1 decline and biomarkers in blood, sputum or urine in Pre-COPD and Mild-COPD patients |
| Lung function decline and Image markers in Pre-COPD and Mild-COPD patients | 2 years | Association between FEV1 decline and structural markers form chest CT scan in Pre-COPD and Mild-COPD patients |
Countries
China
Contacts
Primary ContactKe Huang, M.D.
Backup ContactJieping Lei, PhD
Outcome results
None listed