Cannabis Use
Conditions
Brief summary
The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.
Interventions
DRUG[11C]UCB-J PET
Single PET scan using the radioligand \[11C\]UCB-J
Sponsors
Yale University
National Institute on Drug Abuse (NIDA)
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Able to provide informed consent * Male or female, aged ≥50 years * No history of significant medical or neurological disease * BMI ≤ 50 * If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans
Exclusion criteria
* Women with a positive pregnancy test or women who are lactating * Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits; * History of a bleeding disorder or are currently taking anticoagulants * Subjects who have donated blood within 8 weeks of the present study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hippocampal synaptic density | 1 month | Measure of synaptic density in the hippocampus |
Countries
United States
Contacts
CONTACTAngerlyk Frytz, MD
PRINCIPAL_INVESTIGATORDeepak C D'Souza, MBBS, MD
Yale University
Outcome results
None listed