Gynecologic Disease
Conditions
Keywords
Erector Spinae Plane Block, Quadratus Lumborum Block, Analgesia, Laparoscopic Hysterectomy, Ultrasound Guidance
Brief summary
Postoperative pain following laparoscopic hysterectomy is a challenging concern as some patients suffer acute pain that could let to chronic pain over time following the surgery. Epidural analgesia which is the gold standard for postoperative pain management in abdominal surgeries including laparoscopic hysterectomy has side effects such as hypotension, hematoma, motor weakness of lower limbs, paresthesia, intrathecal placement of the epidural catheter and urinary retention that could prolong hospital stay. Since high frequency ultrasound machines' usage has increased in postoperative analgesia management, ultrasound guided fascial plane blocks has been performed by clinicians with high success rate. To avoid possible complications of epidural catheter placement and epidural analgesia, various techniques has been applying for an analgesic effect close to the effectiveness of epidural analgesia. These techniques include transversus abdominis plane block, rectus sheath block, wound infiltration of local anesthetics, erector spinae plane block and quadratus lumborum plane block . However, each of the plane blocks has limitations individually which prevent them to be the unique analgesic technique for postoperative analgesia following abdominal surgery. As far as the authors knowledge, there's no reported study which compares ultrasound guided erector spinae plane block versus ultrasound guided quadratus lumborum type III block (anterior quadratus lumborum block) as a preemptive analgesia technique in patients undergoing laparoscopic hysterectomy.
Detailed description
Total laparoscopic hysterectomy is the most preferred technique for hysterectomy in obstetric and gynecology clinics (1). The management of postoperative pain in gynecologic laparoscopic surgery is challenging (2, 3). Due to side effects of opioids such as nausea and vomiting, titration of opioid dosage for postoperative pain is difficult and effective postoperative analgesic regimes is needed (3-5). Ultrasound guided regional anesthesia techniques such as erector spinae plane block and quadratus lumborum block for postoperative pain management has an acceleration in usage as ultrasound guidance makes the interventions safer and easier to perform, and they contribute to better pain control and pain experience (6). Ultrasound guided quadratus lumborum block for postoperative pain management after abdominal surgery was firstly conceived by Blanco in 26th European Society of Regional Anesthesia Congress in 2007 as a variant of transversus abdominis plane (TAP) block (7). Later on he reported posterior quadratus lumborum block (QLB) in 2013 which is known as QLB II (8). Børglum et. al described the transmuscular quadratus lumborum block (TQL or QLB III) in 2013 which is frequently performed in abdominal wall surgeries (9). QLB III, transmuscular quadratus lumborum block (TQL) and anterior quadratus lumborum block; these are all synonyms and refers to injection of local anesthetic into the anterior thoracolumbar fascia (TLF) which lays between quadratus lumborum muscle and psoas major muscle (10). Erector spinae plane block has being performed by clinicians for abdominal and thoracic surgeries since it was firstly described by Forero et al. in 2016 for analgesia in thoracic neuropathic pain (11-13). In this ultrasound guided technique local anesthetic is applied between the transverse process of the relevant thoracic or lumbar vertebrae and the erector spinae muscle which leads to the spread of the local anesthetic cephalad, caudally and through the paravertebral space (14, 15). The investigators hypothesize that performing ultrasound-guided quadratus lumborum block will be more superior or equal to erector spinae plane block in providing postoperative analgesia for patients undergoing laparoscopic hysterectomy under general anesthesia.
Interventions
PROCEDUREQuadratus Lumborum Block Type III
Patients will receive ultrasound-guided quadratus lumborum block type III with 60 ml of bupivacaine 0.25% followed by general anesthesia.
PROCEDUREErector Spinae Plane Block
Patients will receive ultrasound-guided erector spinae plane block type III with 60 ml of bupivacaine 0.25% followed by general anesthesia.
OTHERNo Block
The patients will receive general anesthesia.
Sponsors
Namik Kemal University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Intervention model description
The patients will be divided randomly by a computer-generated randomization table into three equal groups.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients who accepted to participate and signed written consent * Aged between 18 and 75 * American Society of Anesthesiologists (ASA) physical score I or II * Elective laparoscopic hysterectomy operation
Exclusion criteria
* Patients who declined to participate * BMI \> 35 kg/m2 * Uncontrolled systemic disease * \<18 age and \>75 age * Unable to cooperate (mental retardation) * Low cardiac capacity * Hypersensitivity history to the agents to be used * Coagulopathy * Local infections * Opioid addiction history
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total dose of opioid consumption (tramadol) | in the first 24 hour postoperatively | Total dose of tramadol consumption via patient controlled device |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Visual Analog Scale | measured at at 30 minute, 2, 6, 12, 24th hour postoperatively | On a scale of 0-10, the patient will learn to quantify postoperative pain where 0= No pain and 10= Maximum worst pain. |
| The 1st time to rescue analgesic need | recorded within the first 24 hour postoperatively | The time to ask for postoperative analgesia is the time from the end of operation to patient reporting Visual Analog Scale ≥ 4. |
| Postoperative nausea and vomiting | recorded within the first 24 hour postoperatively | Postoperative nausea and vomiting presence |
Countries
Turkey (Türkiye)
Outcome results
None listed