Biliary Atresia, Cholangitis
Conditions
Brief summary
Cholangitis is the most common postoperative complication of biliary atresia, with a reported incidence of 40-90%, which seriously affects the surgical effect, survival rate and the quality of life and prognosis of patients. Without of direct evidence, the diagnosis of cholangitis sometimes is difficult to make, thus most of them are diagnosed based on the symptoms of children. According to literature reports, different centers and regions have different diagnostic criteria for postoperative cholangitis after hepatic portoenterostomy, which has a great influence on the accuracy of the incidence rate and appropriate treatment of cholangitis, and also brings differences in the analysis of the causes and prognostic factors of cholangitis. Based on the above reasons, we used the Delphi method，in which worldwidely 48 experts participated in, to establish the diagnostic scoring system for postoperative cholangitis after biliary atresia. Now we aimed to verify the specificity and sensitivity of the new scoring system through clinical cases, in order to unify and standardize the diagnostic criteria and provide help for the diagnosis and treatment of cholangitis after biliary atresia.
Interventions
DRUGIntravenous Antibodies
Treatment is usually performed with sensitive third-generation cephalosporins, and medication is adjusted according to blood culture results
Sponsors
Nanjing Children's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
No
Inclusion criteria
① Admission time: 2019.01.01-2021.12.31; ② The first diagnosis after discharge was cholangitis
Exclusion criteria
① Cholangitis after non-Kasai procedure; * Postoperative cholangitis of biliary atresia not operated in the unit; ③ Patient has been treated in other hospitals during this episode; ④ The treatment period for cholangitis is not completed or the patient is discharged automatically.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic cholangitis score | Two years | The values of the two groups' scores were calculated separately |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Score estimates for treatment of cholangitis | Two years | In the cholangitis group, the correlation between evaluation score and treatment was studied |
Countries
China
Contacts
Primary ContactXie Hua, Dr
Backup ContactLu changgui, Dr
Outcome results
None listed