Color Blindness, Color Blindness, Green, Color Blindness, Red, Color Vision Defects
Conditions
Keywords
Color-Correcting Lenses
Brief summary
To demonstrate improved color vision in subjects with color vision deficiencies while wearing color-correcting lenses and after color-correcting lense use.
Detailed description
The long term objective of this study is to extend upon research demonstrating improvements in color vision deficiencies (CVDs) while wearing color-correcting lenses (CCLs) and after wearing CCLs. Recordings of brainwaves and eye-waves will be made to assess the retina, optic nerve and brain in order to localize where adaptive changes in the visual system are occurring in response to wearing CCLs.
Interventions
DEVICEExperimental Group 1: Color Correcting Lenses
Color Correcting Lenses
DEVICEPlacebo Group 1: Placebo Lenses
Placebo Lenses
DEVICEPlacebo Group 1 Crosses over to become Experimental Group 2: Color Correcting Lenses
Color Correcting Lenses
DEVICEExperimental Group 1 Crosses over to become Placebo Group 2: Placebo Lenses
Placebo Lenses
DEVICEColor Correcting Lenses in Subjects with Normal Color Vision
Color Correcting Lenses
Sponsors
National Eye Institute (NEI)
University of the Incarnate Word
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
Double blind randomized crossover trial
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* no reported history of eye, systemic or ocular disease * VA of 20/30 in each eye * hereditary color vision deficient (CVDs) verified by failing scores on the red-green anomaloscope (outside system normal range) and Ishihara testing (3 or more errors on 14 testable plates) * color vision normal (CVNs) verified by passing red-green anomaloscope (outside system normal range) and Ishihara testing (3 or more errors on 14 testable plates)
Exclusion criteria
* reported use of sleep-inducing or wakefulness drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cone Contrast Test | 2 WeekS | Cone Contrast Sensitivity (CS) Test (CCT, Innova Systems, Inc.): red, green & blue cone CS using 100-point scale based on log changes in CS. Values will be converted to Z-scores to compare to outcomes with other units. |
| Cone Contrast Naming Test | 2 Weeks | Red, green & blue cone CS and color naming accuracy each based on 100-point scale. Values will be converted to Z-scores to compare to outcomes with other units. |
| Letter Chart Testing | 2 Weeks | Letter chart cone specific VA, small letter CS, and large letter CS scored as number of letters correct with VA expressed as log MAR & CS as log CS. Values will be converted to Z-scores to compare to outcomes with other units. |
| Color Matching | 2 Weeks | Cone specific color matching provides the contrast seen by the normal cone type which matches the contrast seen by the defective cone type in units of % Weber contrast. Values will be converted to Z-scores to compare to outcomes with other units. |
| Color Identification Test | 2 Weeks | Cockpit color identification test measure reaction time in seconds and error rate to identify colored targets on a computer display. Values will be converted to Z-scores to compare to outcomes with other units. |
| Visual Electrodiagnostic Testing | 2 Weeks | Cone specific visual brainwaves (VEPs) and flash and pattern eye waves (ERGs) will be quantified in terms of amplitude in microvolts and latency in msec. Values will be converted to Z-scores to compare to outcomes with other units. |
Countries
United States
Outcome results
None listed