Anesthesia
Conditions
Keywords
Hemodynamics, Low Flow Anesthesia, Near Infrared Spectroscopy, Prone Positioning, Regional Cerebral Oxygenation
Brief summary
Low flow anesthesia in the prone position was safe in terms of systemic hemodynamics and did not reduce cerebral oxygenation compared to normal flow.
Detailed description
Patients were randomly allocated to either low fresh gas flow(LF, 0,5 L/min during maintenance) or normal flow (NF, 2 L/min)) general anesthesia. In both groups, participants were first administered with 100% oxygen at a 4 L/min flow rate. Propofol 2-2,5 mg/kg, rocuronium bromide 0,6 mg/kg, and fentanyl 1 mcg/kg IV were used for anesthesia induction.In the operating room, pulse rate, mean arterial pressure (MAP), peripheral hemoglobin oxygen saturation (spO2), and right and left side regional cerebral oxygen saturation (Masimo's O3 regional oximetry device) were measured before premedication and anesthesia induction, at 10 minutes after endotracheal intubation, at 10 minutes after prone positioning, at 1st, 2nd, 3rd, 4th and 5th hours of operation, before repositioning to supine, after the resumption of supine position and at 5 minutes after extubation. In conclusion, low flow anesthesia in patients undergoing surgery in the prone position did not cause a reduction in cerebral oxygenation compared to normal flow.
Interventions
PROCEDURELow Fresh Gas Flow in Prone Position
In the low fresh gas flow group, the flow rate was reduced to 0.5 L/min
PROCEDURENormal Fresh Gas Flow in Prone Position
In the normal flow rate group, the gas flow rate was reduced to 2 L/min during the maintenance phase.
Sponsors
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* undergoing surgery in the prone position * having an American Society of Anesthesiologists (ASA) physical status I to III * willingness to participate in the study
Exclusion criteria
* having a Glasgow coma scale (GSC) score ≤ 12 * previous history of cranial surgery * advanced cardiovascular and/or pulmonary disease * mental retardation * neurological disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Low and Normal Fresh Gas Flow Difference in Prone Position | Systemic and cerebral oxygenation values were measured 10 minutes after induction to general anesthesia and followed up to 10 minutes were left to completion of the surgery for about 5 hours, which may vary according to the duration of the surgery. | Whether low flow anesthesia in the prone position is safe in terms of systemic hemodynamics and cerebral oxygenation compared to normal flow anesthesia |
Countries
Turkey (Türkiye)
Outcome results
None listed