Seizure, Epileptic
Conditions
Brief summary
The purpose is to study the population pharmacokinetics, effectiveness and safety of antiepileptic drug (phenytoin, carbamazepine, lamotrigine, levetiracetam, parempanel, etc) in elderly patients and recommend optimized dosage regimens.
Interventions
phenytoin, carbamazepine, lamotrigine, levetiracetam, perampanel, etc. as part of routine treatment.
Sponsors
Qianfoshan Hospital
The Second Hospital of Shandong University
The Affiliated Hospital of Qingdao University
Wei Zhao
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
1. Age ≥65 years old; 2. Diagnosed with epilepsy; 3. Using antiepileptic drugs for treatment;
Exclusion criteria
1. Patients who are expected to die within 48 hours; 2. Patients with allergy to antiepileptic drugs; 3. Patients receiving other investigational drugs; 4. Other factors that the researcher considers unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The peak plasma drug concentration of antiepileptic drugs. | at (0-4) h after oral administration | To detect the peak plasma drug concentration of antiepileptic drugs. |
| The random plasma drug concentration of antiepileptic drugs. | at (4-10) h after oral administration | To detect the random plasma drug concentration of antiepileptic drugs. |
| The trough plasma drug concentration of antiepileptic drugs. | at (1-2) h before the next administration | To detect the trough plasma drug concentration of antiepileptic drugs. |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of adverse drug reaction | Through study completion, an average of 14 days |
| The frequency of seizures | Through study completion, an average of 14 days |
Countries
China
Contacts
Primary ContactWei Zhao
Outcome results
None listed