Pulmonary Hypertension, Hypersensitivity Pneumonitis
Conditions
Brief summary
Hypersensitivity pneumonitis (HP) is a complex immune mediated disorders caused by repeated inhalation of and sensitization to wide range of antigens including organic particles and chemical compounds, leading to exaggerated immuneresponse. Hypersenstivity pneumonitis is a common form of diffuse parenchymal lung diseases in Egypt .Pulmonary hypertension has been found as a complication of a number of diseases affecting the lung interstitium, including hypersensitivity pneumonitis, with subsequent affection of the life expectancy Rationale of the study: to find predictors for the development of pulmonary hypertension in patients with hypersensitivity pneumonitis
Detailed description
Cross sectional study included 60 patients with established diagnosis of HP , work up includes history of exposure, clinical examination, HRCT chest, ABGs,6MWD, desaturation degree , spirometry, echocardiography and right heart catheter in patients with high echo probability of PH.
Interventions
PROCEDURERight heart catheter
Right heart catheterization was performed for 4 cases with high probability of pulmonary hypertension using multi-lumen swan ganz catheter.
Sponsors
Cairo University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
29 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* All patients with confirmed diagnosis of Hypersensitivity pneumonitis
Exclusion criteria
* Other interstitial lung diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of pulmonary hypertension in patients with HP | 6 months | primary oucome |
Countries
Egypt
Outcome results
None listed