Postoperative Delirium
Conditions
Brief summary
This research project is an observational cohort study by prospective chart review of patients that underwent surgery in multi-centers, China, in the years 2020-2022. The purpose of this study is to compare the occurrence of postoperative delirium With Midazolam and Without Midazolam During Non-cardiac Surgery in Elders.
Detailed description
Post operative delirium will be diagnosed using the 3D- CAM(Confusion Assessment Method) which tests for four features with a series of questions. The features include 1) acute onset and fluctuating course,2) inattention,3) disorganized thinking and 4) altered level of consciousness. Diagnosis of delirium is made if features 1 and 2 and either 3 or 4 are present. The demographic data of the patients,type and site of surgery will be noted. Preoperative hemoglobin, serum electrolytes and blood urea will be recorded. The intraoperative factors like duration of surgery and anaesthesia,use of intravenous fluids ,blood loss, number blood units transfused and opioid use will be studied at the time of surgery. The time to emergence and extubation following the completion of surgery will be noted. The postoperative factors like postoperative pain, nausea and vomiting, fever,hemoglobin,serum electrolytes and blood urea will be noted. Preoperative and postoperative pain will be assessed using the numerical rating score on a scale of one to ten. The association of various preoperative,intraoperative and postoperative factors with POD will be determined.
Interventions
DRUGMidazolam
Midazolam as a premedication was given as the patient is taken to the operating room and typically within 15 minutes of anesthetic induction.
Sponsors
Beijing Tiantan Hospital
Peking University First Hospital
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Xiangya Hospital of Central South University
Beijing Anzhen Hospital
China-Japan Friendship Hospital
Fudan University
Central South University
Peking University People's Hospital
Zhejiang University
Sun Yat-sen University
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Taihe Hospital
The Affiliated Hospital Of Guizhou Medical University
First Affiliated Hospital of Xinjiang Medical University
First Affiliated Hospital of Guangxi Medical University
Zhejiang Provincial People's Hospital
Chinese PLA General Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Inclusion criteria
Geriatric surgical patients ≥65 years old Underwent elective non-cardiac surgery
Exclusion criteria
History of neuropsychiatric diseases including delirium, mental disorders, Parkinson, dementia, etc.; The operation was cancelled due to various reasons after the patient was enrolled; severe liver disease; severe renal dysfunction defined as either having creatinine clearance \< 30 ml/min or being dialysis-dependent; Patients who undergo second operation in a short period; Refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of postoperative delirium | Day 1 postoperatively | Occurrence of delirium on any postoperative day, as assessed using the 3D-CAM or CAM-ICU daily |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of survival rate | 1 year | collection of clinical data in the medical record and follow-up update |
Countries
China
Outcome results
None listed