Effect of Drug
Conditions
Brief summary
Cannabidiol, or CBD, is an over-the-counter nutraceutical that is more commonly being used by healthy adults for pain management, recovery from strenuous exercise, and general wellness. However, little research exists on the effects of CBD in otherwise healthy individuals. This study uses iontophoresis, a common technique used in physical therapy, to determine the effectiveness of topical CBD in lessening the reflex increased cutaneous vascular conductance response to stimulation of the skin.
Interventions
BIOLOGICALCannabidiol
Urbal Activ Extra Strength CBD Body Strong Balm applied to region of forearm to be stimulated by iontophoresis machine
Sponsors
Penn State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Men and women 18 years of age and older * English speaking * Non-obese class III, BMI ≤ 39.9 * Normal HbA1C of \<6.5%
Exclusion criteria
* Abnormal resting heart rate (\<60 or \>100 bpm) or BP (systolic \<100 or \>129 mmHg, diastolic \<60 or \>100 mmHg) values * Rash, skin disease, disorders of pigmentation * Known skin allergies * Diabetes * Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.) * Illegal drug use * Recent (within the last 30 days) CBD users either topical or oral * Allergy or hypersensitivity to investigational agents * Women who are pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cutaneous Vascular Conductance | ~5 hours | pulse units as measured by laser Doppler flowmetry |
Countries
United States
Outcome results
None listed