Deprescriptions, End-Of-Life, Geriatrics, Inappropriate Prescribing, Palliative Medicine
Conditions
Brief summary
This study's main objective is to investigate whether the application of an adapted person-centred prescription model during a hospital stay would reduce the use of inappropriate or futile regular medications in older people at the end of life, improving their clinical/health statuses and reducing the expense associated with pharmacological treatment. We hypothesised that applying this modified method could optimise pharmacotherapeutic indicators and the expense associated with the pharmacological treatment of hospitalised patients
Interventions
OTHERPerson-Centred Prescription Model
Step 1: Identify patients with advanced chronic condition and limited life expectancy. Step 2: Interview with patients or closes caregiver. Step 3: Medication Review The clinical pharmacist conduct a structured medication review based on the medication appropriateness index (MAI): * Indication/effectiveness: Product information, STOPPFrail (Screening Tool of Older Persons' Prescriptions in Frail adults with limited life expectancy) criteria and Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. * Dosage adjustment: Product Information and Lexi-Comp's Geriatric Dosage Handbook. * Correct and practical directions: Medication Regimen Complexity Index (MRCI). * Drug-drug interactions: Bot Plus/Beers Criteria and drug burden index (DBI), which measures dose-dependent anticholinergic and sedative loads. * Drug-disease interactions: Beers Criteria. * Duplication, duration and cost-effectiveness: Product information. Step 4: Treatment Plan
Sponsors
University of the Basque Country (UPV/EHU)
Universidad de León
Matia Foundation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Comparison of person-centred prescription model application versus standard pharmaceutical care alone. The intervention is applied randomly during hospital stay in hospitalised older people at the end of life. The primary outcome is the mean change between admission and discharge in the number of regular medications.
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the geriatric convalescence unit and identified as having a non-oncological advanced chronic disease and being in need of palliative care, with a limited survival prognosis according to the necessity of palliative care (NECPAL) test.
Exclusion criteria
* Patients with hospital stays of less than 72 hours. * Patients transferred to other hospitals or units. * Patients with imminently terminal patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change between admission and discharge in the number of regular medications. | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Change between admission and discharge in the Drug Burden Index (DBI) | 3 months |
| Change between admission and discharge in the total drug-drug interactions | 3 months |
| Change between admission and discharge in the Medication Regimen Complexity Index (MRCI) | 3 months |
| Change between admission and discharge in the STOPP Frail Criteria | 3 months |
| Number of patients who have had a new emergency department presentation. | 3 months |
| Number of patients who have had unplanned hospital readmission | 3 months |
| Change in the 28-day cost of prescriptions in € | 3 months |
Countries
Spain
Outcome results
None listed