Blood Vessel Injury, Vaping
Conditions
Brief summary
The purpose of this study is to determine how vaping affects blood vessels, in particular if early damage occurs in the lung vessels.
Interventions
None listed
Sponsors
University of Miami
Florida Department of Health
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Vapers Group: 1. Current electronic cigarette (EC) Puff Bar users defined as using EC either daily or occasionally in the past 30 days for at least 6 months, and with 5% nicotine concentration pods. 2. Adults aged 18-40 years Healthy Group: 1. Healthy never smokers, never vapers 2. Adults aged 18-40 years
Exclusion criteria
1. Current or past smoking of tobacco cigarette (TC) or other tobacco/nicotine products (e.g., smokeless tobacco, Hookah) or marijuana will be excluded from the study. 2. Subjects with self-reported history of chronic health problems including asthma, chronic obstructive pulmonary disease (COPD), morbid obesity (BMI\>40 kg/m2), hypertension or diabetes 3. Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Airway blood flow reactivity (QAW) | Up to 1 week | QAW will be measured via soluble gas uptake method |
| Pulmonary vascular resistance (PVR) | Up to 4 weeks | PVR will be measured via echocardiography |
| Flow-mediated vasodilation (FMD) | Up to 4 weeks | FMD will be measured by blood pressure cuff deflation using ultrasound |
Countries
United States
Contacts
CONTACTAdam Wanner, MD
CONTACTMichael Campos, MD
PRINCIPAL_INVESTIGATORAdam Wanner, MD
University of Miami
Outcome results
None listed