Postoperative Delirium
Conditions
Brief summary
This study intends to verify and explore the correlation of neuroinflammation biomarkers in cerebrospinal fluid and plasma of elderly patients undergoing hip replacement with postoperative delirium, so as to achieve a new method to predict whether patients will develop postoperative delirium and improve the prognosis of elderly patients with postoperative delirium. Reduce the probability of postoperative complications, improve the long-term survival rate of patients after surgery.
Interventions
BEHAVIORALpostoperative delirium
Postoperative delirium (POD) occurs within 1 week after surgery in patients, with obvious time characteristics, mainly occurring within 1-3 days after surgery. Postoperative delirium has adverse effects on the short and long term prognosis of patients. Patients with delirium have an increased risk of postoperative complications, perioperative death, longer hospital stay and increased medical costs during hospitalization.
Sponsors
Henan Provincial People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. age≥65 2. Patients undergoing hip replacement under spinal anesthesia 3. ASA grade I\ III; 4. Voluntarily participate in this study, and informed consent was signed by the patients themselves and their families
Exclusion criteria
1. Patients with multiple fractures and trauma 2. Patients with preoperative cognitive dysfunction determined by MMSE scale; 3. Severe impairment of hearing, visual and language system functions; 4. Not suitable for or unwilling to undergo subarachnoid anesthesia 5. Patients who refuse to participate or cannot cooperate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neuroinflammatory biomarkers | preoperative、24 hours after surgery、48 hours after surgery | Whether there are changes in neuroinflammatory biomarkers(Ykl40(pg/mL), procalcitonin(ng/mL), IL-17A,IL-23,INF-γ(IU), Tau(pg/mL), amyloid beta(pg/mL),etc) in cerebrospinal fluid and plasma between delirium patients and non-delirium patients before and after operation. |
Countries
China
Contacts
Primary ContactZhaoyu Wen, Bachelor
Outcome results
None listed