Brain Diseases, Hypertension
Conditions
Brief summary
The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a large sample size of subjects (participants), to identify the influencing factors of the occurrence and development of cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs, so as to provide objective clues for early intervention of the disease and improve clinical outcomes.
Interventions
This is an observational study.
Sponsors
KaiLuan General Hospital
Beijing Friendship Hospital
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age from 18 to 90 years old; 2. Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured; 3. Without contraindications of CT and MR scan; 4. Can cooperate with the measurement of the medical history, physiological indicators and brain imaging.
Exclusion criteria
1. Known clinical history with congenital or acquired organic diseases (such as aortic stenosis); 2. Known history of drug abuse; 3. Pregnant and lactating women; 4. With clinical history of psychiatric diseases (such as schizophrenia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain volume measured by MRI (magnetic resonance imaging) | every two years up to 30 years |
| White matter microstructural integrity of the brain measured by MRI (magnetic resonance imaging) | every two years up to 30 years |
| White matter hyperintensity of the brain measured by MRI (magnetic resonance imaging) | every two years up to 30 years |
| microbleeds of the brain measured by MRI (magnetic resonance imaging) | every two years up to 30 years |
| Lacunes of the brain measured by MRI (magnetic resonance imaging) | every two years up to 30 years |
| Cerebral blood flow measured by MRI (magnetic resonance imaging) | every two years up to 30 years |
Secondary
| Measure | Time frame |
|---|---|
| Uric acid | every two years up to 30 years |
| BMI (body mass index) | every two years up to 30 years |
| blood glucose level | every two years up to 30 years |
| Cervical vascular ultrasound | every two years up to 30 years |
| Fundus color photography of the eyes | every two years up to 30 years |
| Fundus optical coherence tomography (OCT) | every two years up to 30 years |
| Blood pressure (both Systolic and Diastolic Blood Pressure) | every two years up to 30 years |
Other
| Measure | Time frame |
|---|---|
| Pulse Wave Velocity, PWV | every two years up to 30 years |
| Lipoprotein | every two years up to 30 years |
Countries
China
Contacts
Primary ContactZhenchang Wang
Backup ContactJing Li
Outcome results
None listed