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Mindfulness Training, Mental Fatigue, Endurance Performance and Neurocognitive Functions

Effect of Mindfulness Training on Mental Fatigue-Related Impairments of Endurance Performance and Inhibitory Control in Athletes: An Event-Related Potential Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05452460
Enrollment
53
Registered
2022-07-11
Start date
2022-02-17
Completion date
2023-01-10
Last updated
2025-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental Fatigue, Mindfulness Training, Neurocognitive Function, Sports Performance

Keywords

Mindfulness Training, Mental Fatigue, Inhibitory Control, Endurance Performance, ERP

Brief summary

Mental fatigue has been suggested that would impair neurocognitive functions and sports performance. On the other hand, mindfulness training (MT) seems to as a promising approach to attenuate mental fatigue and counteract its detrimental effect on cognitive functions and sports performance. The purpose of the present study is to examine the effect of MT on behavioral and neuroelectric indices of inhibitory control, and endurance performance in mentally fatigued athletes.

Detailed description

Accumulating research indicates that mental fatigue induced by prolonged cognitive tasks would impair neurocognitive functions and sports performance. Additionally, recent studies demonstrate that inhibitory control and endurance performance are significantly susceptible to detrimental effects of mental fatigue. On the other hand, mindfulness training (MT) has been widely been used to enhance cognitive functions and sports performance in neurocognitive and sports research, which has been considered a promising approach for attenuating mental fatigue and counteracting the detrimental effect of mental fatigue. However, the effect of MT on inhibitory control, endurance performance, and underlying mechanisms in mentally fatigued athletes remain unclear. Therefore, the purpose of the present study is to examine the effect of MT on behavioral and neuroelectric indices of inhibitory control, and endurance performance in mentally fatigued athletes. Specifically, the targeted primary outcomes are neurocognitive functions (i.e., reaction time, accuracy and ERPs in Flanker task) and endurance performance (i.e., VO2max & time to exhaustion); The secondary outcomes are changes in dispositional mindfulness, subjective (i.e., scores in visual analog scale)/objective (i.e., reaction time, accuracy in Stroop task) mental fatigue, motivation in tasks, and changes in mood state (i.e., BRUMS-C).

Interventions

BEHAVIORALMindfulness intervention

The mindfulness program called Mindfulness-based peak performance (MBPP) will be used in this study. MBPP is a program that consists of eight 60-min training, and a 60-min session weekly for 8-weeks. The MBPP program will include (1) 5 minutes of will start with a brief recap of the preceding session and homework discussion, (2) after which the 5 minutes of a brief story about performance aimed at inducing the learning motivation of the participants; (3) Followed by 20 minutes of a theoretical lecture introducing a new topic and then (4) 25 minutes of mindfulness exercise. (5) Finally, how to apply the mindfulness skills to sports context will be discussed at the end of each session for 5 minutes.

Sponsors

National Taiwan Normal University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

1. Regular sports training at least 4 hours weekly 2. Normal or corrected-to-normal vision 3. Right-handed

Exclusion criteria

1. Physical limitation or injury in lower limbs before and during the study 2. Diagnosed or self-reported neurological disorders (e.g., epilepsy) 3. Diagnosed or self-reported major psychiatric illness (e.g., major depression, schizophrenia) 4. Major previous experience with mindfulness training

Design outcomes

Primary

MeasureTime frameDescription
Inhibitory Control: Reaction TimeAfter 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)Followed by the manipulation conditions, inhibitory control will be evaluated by a Flanker task (i.e., either mental fatigue condition or control condition). In the Flanker task, participants will be presented with five arrows and will be instructed to respond as quickly and accurately as possible to the direction where the middle arrow is pointing (i.e., left or right). Types of trials are the congruent (i.e., \> \> \> \> \>) and incongruent (i.e., \< \< \> \< \<). The reaction time (RT) and accuracy (ACC) of the incongruent trials were calculated as inhibitory control performance, and the difference between conditions was further calculated to represent a mental fatigue-related impairment of inhibitory control in pre-test and post-test.
Inhibitory Control: AccuracyAfter 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)Followed by the manipulation conditions, inhibitory control will be evaluated by a Flanker task (i.e., either mental fatigue condition or control condition). In the Flanker task, participants will be presented with five arrows and will be instructed to respond as quickly and accurately as possible to the direction where the middle arrow is pointing (i.e., left or right). Types of trials are the congruent (i.e., \> \> \> \> \>) and incongruent (i.e., \< \< \> \< \<). The reaction time (RT) and accuracy (ACC) of the incongruent trials were calculated as inhibitory control performance, and the difference between conditions was further calculated to represent a mental fatigue-related impairment of inhibitory control in pre-test and post-test.
ERP: N2After 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)The neuroelectrical activities (i.e., N2, P3) during the Flanker task were recorded and analyzed using the Neuroscan system. The difference in neuroelectrical activities between conditions (i.e., mental fatigue condition & control condition) were calculated as mental fatigue-related impairment in neuroelectrical markers of inhibitory control.
ERP: P3After 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)The neuroelectrical activities (i.e., N2, P3) during the Flanker task were recorded and analyzed using the Neuroscan system. The difference in neuroelectrical activities between conditions (i.e., mental fatigue condition & control condition) were calculated as mental fatigue-related impairment in neuroelectrical markers of inhibitory control.
Endurance Performance: Time to ExhaustionAfter 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)The graded exercise test (GXT) on treadmill was used to assess participant's endurance performance. Bruce protocol will be adopted in the test. The initial speed and grade of the GXT will be set at 2.74 km/hr with a grade of 10% and increase speed and grade every 3 min until participants are voluntarily exhausted. The time to exhaustion (TTE) was recorded as the endurance performance. The difference in TTE between conditions was further calculated (i.e., control condition minus mental fatigue condition) for both the pre-test and post-test.
Endurance Performance: VO2maxAfter 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)The graded exercise test (GXT) on treadmill was used to assess participant's endurance performance. Bruce protocol will be adopted in the test. The initial speed and grade of the GXT will be set at 2.74 km/hr with a grade of 10% and increase speed and grade every 3 min until participants are voluntarily exhausted. The maximum oxygen consumption (VO2 max) was recorded as the endurance performance. The difference in VO2max between conditions was further calculated (i.e., control condition minus mental fatigue condition) for both the pre-test and post-test.

Secondary

MeasureTime frameDescription
Mood State: FatigueBefore, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher fatigue mood.
Mood State: TensionBefore, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher tension mood.
Subjective Mental FatigueBefore, after 30-minute Stroop task and after Flanker task in the mental fatigue and control condition at pre-test and post-test (8 weeks)Both in the baseline and post-intervention, the visual analog scale for mental fatigue (VAS-MF) was used to assess changes in subjective mental fatigue before and after experimental manipulation. The scale ranges from 0 (not at all mentally fatigued) to 100 (extremely mentally fatigued).
Perception of Effortevery 2.5 minutes during graded exercise testDuring the graded exercise test, the perception of effort will be asked at beginning and every 2.5-min using Borg 6 to 20 scale, until the participant comes to voluntary exhaustion.
Mood State: VigourBefore, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher vigor mood.
Objective Mental FatiguePost 30-minute mental fatigue and control condition at pre-test and post-test (8 weeks)Both at baseline and post-intervention, participants completed either a 30-min 100% incongruent version Stroop task (i.e., mental fatigue condition) or a 30-min 100% congruent version Stroop task (i.e., control condition). In the Stroop task, accuracy (ACC) was calculated as an index of objective mental fatigue. It is expressed as a percentage, determined by dividing the number of correct responses by the total number of responses.
Dispositional MindfulnessBaseline (pre-test) and 8 weeks (post-test)The change in dispositional mindfulness was assessed using the 16-item (5-Likert scale) athlete mindfulness questionnaire (AMQ). The mean score range is between 1-5. Higher mean scores indicate a higher level of dispositional mindfulness.
Mood State: AngerBefore, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher anger mood.
Mood State: ConfusionBefore, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher confusion mood.
Mood State: DepressionBefore, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher depression mood.

Countries

Taiwan

Participant flow

Pre-assignment details

No participants were excluded from the study before assignment to groups.

Participants by arm

ArmCount
Mindfulness Training Group
Participants in the mindfulness training (MT) group will engage in a 60-min session of mindfulness program per week for 8 weeks. Mindfulness intervention: The mindfulness program called Mindfulness-based peak performance (MBPP) will be used in this study. MBPP is a program that consists of eight 60-min training, and a 60-min session weekly for 8-weeks. The MBPP program will include (1) 5 minutes of will start with a brief recap of the preceding session and homework discussion, (2) after which the 5 minutes of a brief story about performance aimed at inducing the learning motivation of the participants; (3) Followed by 20 minutes of a theoretical lecture introducing a new topic and then (4) 25 minutes of mindfulness exercise. (5) Finally, how to apply the mindfulness skills to sports context will be discussed at the end of each session for 5 minutes.
26
Waitlist Control Group
Participants in the waitlist control group will be required to maintain regular life and routine training. Once the participants in control group finished the whole experiment, they will be invited to participate in the MBPP program for eight weeks.
27
Total53

Withdrawals & dropouts

PeriodReasonFG000FG001
Overall StudyDid not receive intervention10
Overall StudyLost to Follow-up33

Baseline characteristics

CharacteristicWaitlist Control GroupTotalMindfulness Training Group
Age, Continuous20.22 years
STANDARD_DEVIATION 1.5
20.15 years
STANDARD_DEVIATION 1.42
20.08 years
STANDARD_DEVIATION 1.35
Education level14.44 years
STANDARD_DEVIATION 1.4
14.40 years
STANDARD_DEVIATION 1.35
14.35 years
STANDARD_DEVIATION 1.32
Height168.72 centimeter (cm)
STANDARD_DEVIATION 6.62
168.12 centimeter (cm)
STANDARD_DEVIATION 6.75
167.5 centimeter (cm)
STANDARD_DEVIATION 6.96
Race and Ethnicity Not Collected0 Participants
Sex: Female, Male
Female
5 Participants12 Participants7 Participants
Sex: Female, Male
Male
22 Participants41 Participants19 Participants
Sport
Judo
7 Participants12 Participants5 Participants
Sport
Track & field
7 Participants14 Participants7 Participants
Sport
Wrestling
6 Participants11 Participants5 Participants
Sport
Wushu
7 Participants16 Participants9 Participants
Training experience8.18 years
STANDARD_DEVIATION 2.65
8.10 years
STANDARD_DEVIATION 2.39
8.00 years
STANDARD_DEVIATION 2.06
Weight66.88 kilograms (kg)
STANDARD_DEVIATION 10.01
69.17 kilograms (kg)
STANDARD_DEVIATION 20.07
71.55 kilograms (kg)
STANDARD_DEVIATION 26.88
Working memory
Backward digit span
10.22 units on a scale
STANDARD_DEVIATION 2.45
9.75 units on a scale
STANDARD_DEVIATION 2.62
9.27 units on a scale
STANDARD_DEVIATION 2.75
Working memory
Forward digit span
14.22 units on a scale
STANDARD_DEVIATION 1.55
14.28 units on a scale
STANDARD_DEVIATION 1.78
14.35 units on a scale
STANDARD_DEVIATION 2.02

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
0 / 260 / 27
other
Total, other adverse events
0 / 260 / 27
serious
Total, serious adverse events
0 / 260 / 27

Outcome results

Primary

Endurance Performance: Time to Exhaustion

The graded exercise test (GXT) on treadmill was used to assess participant's endurance performance. Bruce protocol will be adopted in the test. The initial speed and grade of the GXT will be set at 2.74 km/hr with a grade of 10% and increase speed and grade every 3 min until participants are voluntarily exhausted. The time to exhaustion (TTE) was recorded as the endurance performance. The difference in TTE between conditions was further calculated (i.e., control condition minus mental fatigue condition) for both the pre-test and post-test.

Time frame: After 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupEndurance Performance: Time to ExhaustionCondition difference in TTE at pre-test28.50 secondStandard Deviation 32.28
Mindfulness Training GroupEndurance Performance: Time to ExhaustionCondition difference in TTE at post-test-20.06 secondStandard Deviation 33.54
Waitlist Control GroupEndurance Performance: Time to ExhaustionCondition difference in TTE at pre-test23.89 secondStandard Deviation 36.43
Waitlist Control GroupEndurance Performance: Time to ExhaustionCondition difference in TTE at post-test13.15 secondStandard Deviation 34.45
p-value: <0.01ANCOVA
Primary

Endurance Performance: VO2max

The graded exercise test (GXT) on treadmill was used to assess participant's endurance performance. Bruce protocol will be adopted in the test. The initial speed and grade of the GXT will be set at 2.74 km/hr with a grade of 10% and increase speed and grade every 3 min until participants are voluntarily exhausted. The maximum oxygen consumption (VO2 max) was recorded as the endurance performance. The difference in VO2max between conditions was further calculated (i.e., control condition minus mental fatigue condition) for both the pre-test and post-test.

Time frame: After 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupEndurance Performance: VO2maxCondition difference in VO2max at pre-test0.86 ml/kg/minStandard Deviation 4.88
Mindfulness Training GroupEndurance Performance: VO2maxCondition difference in VO2max at post-test-0.16 ml/kg/minStandard Deviation 2.92
Waitlist Control GroupEndurance Performance: VO2maxCondition difference in VO2max at pre-test0.92 ml/kg/minStandard Deviation 4.12
Waitlist Control GroupEndurance Performance: VO2maxCondition difference in VO2max at post-test-0.02 ml/kg/minStandard Deviation 3.62
p-value: >0.05ANCOVA
Primary

ERP: N2

The neuroelectrical activities (i.e., N2, P3) during the Flanker task were recorded and analyzed using the Neuroscan system. The difference in neuroelectrical activities between conditions (i.e., mental fatigue condition & control condition) were calculated as mental fatigue-related impairment in neuroelectrical markers of inhibitory control.

Time frame: After 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupERP: N2Condition difference in N2 amplitude at pre-test (incongruent trial)-1.27 μVStandard Deviation 3.48
Mindfulness Training GroupERP: N2Condition difference in N2 amplitude at post-test (incongruent trial)0.72 μVStandard Deviation 4.07
Waitlist Control GroupERP: N2Condition difference in N2 amplitude at pre-test (incongruent trial)-1.14 μVStandard Deviation 4.85
Waitlist Control GroupERP: N2Condition difference in N2 amplitude at post-test (incongruent trial)0.18 μVStandard Deviation 2.58
p-value: >0.05ANCOVA
Primary

ERP: P3

The neuroelectrical activities (i.e., N2, P3) during the Flanker task were recorded and analyzed using the Neuroscan system. The difference in neuroelectrical activities between conditions (i.e., mental fatigue condition & control condition) were calculated as mental fatigue-related impairment in neuroelectrical markers of inhibitory control.

Time frame: After 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupERP: P3Condition difference in P3 amplitude at pre-test (incongruent trial)-0.28 μVStandard Deviation 3.85
Mindfulness Training GroupERP: P3Condition difference in P3 amplitude at post-test (incongruent trial)0.78 μVStandard Deviation 6.05
Waitlist Control GroupERP: P3Condition difference in P3 amplitude at pre-test (incongruent trial)0.19 μVStandard Deviation 5.23
Waitlist Control GroupERP: P3Condition difference in P3 amplitude at post-test (incongruent trial)-0.69 μVStandard Deviation 5.6
p-value: >0.05ANCOVA
Primary

Inhibitory Control: Accuracy

Followed by the manipulation conditions, inhibitory control will be evaluated by a Flanker task (i.e., either mental fatigue condition or control condition). In the Flanker task, participants will be presented with five arrows and will be instructed to respond as quickly and accurately as possible to the direction where the middle arrow is pointing (i.e., left or right). Types of trials are the congruent (i.e., \> \> \> \> \>) and incongruent (i.e., \< \< \> \< \<). The reaction time (RT) and accuracy (ACC) of the incongruent trials were calculated as inhibitory control performance, and the difference between conditions was further calculated to represent a mental fatigue-related impairment of inhibitory control in pre-test and post-test.

Time frame: After 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupInhibitory Control: AccuracyCondition difference in ACC of Flanker task (pre-test)6.15 percentage of correct responseStandard Deviation 11.79
Mindfulness Training GroupInhibitory Control: AccuracyCondition difference in ACC of Flanker task (post-test)2.60 percentage of correct responseStandard Deviation 6.12
Waitlist Control GroupInhibitory Control: AccuracyCondition difference in ACC of Flanker task (pre-test)2.32 percentage of correct responseStandard Deviation 11.97
Waitlist Control GroupInhibitory Control: AccuracyCondition difference in ACC of Flanker task (post-test)2.61 percentage of correct responseStandard Deviation 4.83
p-value: >0.05ANCOVA
Primary

Inhibitory Control: Reaction Time

Followed by the manipulation conditions, inhibitory control will be evaluated by a Flanker task (i.e., either mental fatigue condition or control condition). In the Flanker task, participants will be presented with five arrows and will be instructed to respond as quickly and accurately as possible to the direction where the middle arrow is pointing (i.e., left or right). Types of trials are the congruent (i.e., \> \> \> \> \>) and incongruent (i.e., \< \< \> \< \<). The reaction time (RT) and accuracy (ACC) of the incongruent trials were calculated as inhibitory control performance, and the difference between conditions was further calculated to represent a mental fatigue-related impairment of inhibitory control in pre-test and post-test.

Time frame: After 30-minute mental fatigue and control conditions at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupInhibitory Control: Reaction TimeCondition difference in RT of Flanker task (pre-test)10.79 millisecondStandard Deviation 57.89
Mindfulness Training GroupInhibitory Control: Reaction TimeCondition difference in RT of Flanker task (post-test)4.11 millisecondStandard Deviation 19.63
Waitlist Control GroupInhibitory Control: Reaction TimeCondition difference in RT of Flanker task (pre-test)5.47 millisecondStandard Deviation 42.72
Waitlist Control GroupInhibitory Control: Reaction TimeCondition difference in RT of Flanker task (post-test)-0.61 millisecondStandard Deviation 19.9
p-value: >0.05ANCOVA
Secondary

Dispositional Mindfulness

The change in dispositional mindfulness was assessed using the 16-item (5-Likert scale) athlete mindfulness questionnaire (AMQ). The mean score range is between 1-5. Higher mean scores indicate a higher level of dispositional mindfulness.

Time frame: Baseline (pre-test) and 8 weeks (post-test)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupDispositional MindfulnessAMQ score in pre-test3.94 score on a scaleStandard Deviation 0.59
Mindfulness Training GroupDispositional MindfulnessAMQ score in post-test4.13 score on a scaleStandard Deviation 0.55
Waitlist Control GroupDispositional MindfulnessAMQ score in post-test3.87 score on a scaleStandard Deviation 0.44
Waitlist Control GroupDispositional MindfulnessAMQ score in pre-test4.04 score on a scaleStandard Deviation 0.53
p-value: <0.05ANCOVA
Secondary

Mood State: Anger

Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher anger mood.

Time frame: Before, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupMood State: AngerChange of anger in pre-mental fatigue condition0.13 score on a scaleStandard Deviation 0.64
Mindfulness Training GroupMood State: AngerChange of anger in post-mental fatigue condition0.21 score on a scaleStandard Deviation 0.52
Mindfulness Training GroupMood State: AngerChange of anger in pre-control condition0.12 score on a scaleStandard Deviation 0.38
Mindfulness Training GroupMood State: AngerChange of anger in post-control condition-0.04 score on a scaleStandard Deviation 0.36
Waitlist Control GroupMood State: AngerChange of anger in post-control condition-0.03 score on a scaleStandard Deviation 0.31
Waitlist Control GroupMood State: AngerChange of anger in pre-mental fatigue condition0.06 score on a scaleStandard Deviation 0.24
Waitlist Control GroupMood State: AngerChange of anger in pre-control condition0.37 score on a scaleStandard Deviation 0.49
Waitlist Control GroupMood State: AngerChange of anger in post-mental fatigue condition0.05 score on a scaleStandard Deviation 0.33
p-value: >0.05ANCOVA
Secondary

Mood State: Confusion

Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher confusion mood.

Time frame: Before, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupMood State: ConfusionChange of confusion in pre-mental fatigue condition0.59 score on a scaleStandard Deviation 0.78
Mindfulness Training GroupMood State: ConfusionChange of confusion in post-mental fatigue condition0.70 score on a scaleStandard Deviation 0.63
Mindfulness Training GroupMood State: ConfusionChange of confusion in pre-control condition0.37 score on a scaleStandard Deviation 0.49
Mindfulness Training GroupMood State: ConfusionChange of confusion in post-control condition0.18 score on a scaleStandard Deviation 0.4
Waitlist Control GroupMood State: ConfusionChange of confusion in post-control condition0.30 score on a scaleStandard Deviation 0.56
Waitlist Control GroupMood State: ConfusionChange of confusion in pre-mental fatigue condition0.56 score on a scaleStandard Deviation 0.75
Waitlist Control GroupMood State: ConfusionChange of confusion in pre-control condition0.29 score on a scaleStandard Deviation 0.54
Waitlist Control GroupMood State: ConfusionChange of confusion in post-mental fatigue condition0.50 score on a scaleStandard Deviation 0.56
p-value: >0.05ANCOVA
Secondary

Mood State: Depression

Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher depression mood.

Time frame: Before, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupMood State: DepressionChange of depression in pre-mental fatigue condition0.07 score on a scaleStandard Deviation 0.56
Mindfulness Training GroupMood State: DepressionChange of depression in pre-control condition0.12 score on a scaleStandard Deviation 0.38
Mindfulness Training GroupMood State: DepressionChange of depression in post-mental fatigue condition0.17 score on a scaleStandard Deviation 0.5
Mindfulness Training GroupMood State: DepressionChange of depression in post-control condition-0.01 score on a scaleStandard Deviation 0.25
Waitlist Control GroupMood State: DepressionChange of depression in post-control condition-0.07 score on a scaleStandard Deviation 0.38
Waitlist Control GroupMood State: DepressionChange of depression in post-mental fatigue condition0.14 score on a scaleStandard Deviation 0.52
Waitlist Control GroupMood State: DepressionChange of depression in pre-control condition-0.01 score on a scaleStandard Deviation 0.28
Waitlist Control GroupMood State: DepressionChange of depression in pre-mental fatigue condition0.05 score on a scaleStandard Deviation 0.38
p-value: >0.05ANCOVA
Secondary

Mood State: Fatigue

Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher fatigue mood.

Time frame: Before, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupMood State: FatigueChange of fatigue in post-mental fatigue condition1.04 score on a scaleStandard Deviation 0.9
Mindfulness Training GroupMood State: FatigueChange of fatigue in pre-mental fatigue condition1.23 score on a scaleStandard Deviation 1.07
Mindfulness Training GroupMood State: FatigueChange of fatigue in pre-control condition0.98 score on a scaleStandard Deviation 0.93
Mindfulness Training GroupMood State: FatigueChange of fatigue in post-control condition0.65 score on a scaleStandard Deviation 0.92
Waitlist Control GroupMood State: FatigueChange of fatigue in post-control condition0.64 score on a scaleStandard Deviation 0.81
Waitlist Control GroupMood State: FatigueChange of fatigue in post-mental fatigue condition0.86 score on a scaleStandard Deviation 0.85
Waitlist Control GroupMood State: FatigueChange of fatigue in pre-mental fatigue condition1.26 score on a scaleStandard Deviation 1
Waitlist Control GroupMood State: FatigueChange of fatigue in pre-control condition0.78 score on a scaleStandard Deviation 0.94
p-value: >0.05ANCOVA
Secondary

Mood State: Tension

Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher tension mood.

Time frame: Before, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupMood State: TensionChange of tension in post-control condition-0.00 score on a scaleStandard Deviation 0.35
Mindfulness Training GroupMood State: TensionChange of tension in post-mental fatigue condition0.20 score on a scaleStandard Deviation 0.54
Mindfulness Training GroupMood State: TensionChange of tension in pre-mental fatigue condition0.06 score on a scaleStandard Deviation 0.69
Mindfulness Training GroupMood State: TensionChange of tension in pre-control condition0.07 score on a scaleStandard Deviation 0.4
Waitlist Control GroupMood State: TensionChange of tension in pre-control condition0.04 score on a scaleStandard Deviation 0.54
Waitlist Control GroupMood State: TensionChange of tension in pre-mental fatigue condition0.14 score on a scaleStandard Deviation 0.43
Waitlist Control GroupMood State: TensionChange of tension in post-mental fatigue condition0.11 score on a scaleStandard Deviation 0.42
Waitlist Control GroupMood State: TensionChange of tension in post-control condition-0.05 score on a scaleStandard Deviation 0.41
p-value: >0.05ANCOVA
Secondary

Mood State: Vigour

Mood state change was determined by the difference in scores on the Brunel Mood Scale-Chinese (BRUMS-C) between before and after manipulation. The BRUMS-C contains 23 item (5-Likert scale) and is divided into six sub-scales: anger, confusion, depression, fatigue, tension, and vigour. The mean score range is between 0-4. Higher mean scores indicate a higher vigor mood.

Time frame: Before, after 30-minute Stroop task in the mental fatigue and control condition at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupMood State: VigourChange of vigour in post-mental fatigue condition-0.74 score on a scaleStandard Deviation 0.75
Mindfulness Training GroupMood State: VigourChange of vigour in pre-mental fatigue condition-0.92 score on a scaleStandard Deviation 0.78
Mindfulness Training GroupMood State: VigourChange of vigour in pre-control condition-0.81 score on a scaleStandard Deviation 0.78
Mindfulness Training GroupMood State: VigourChange of vigour in post-control condition-0.49 score on a scaleStandard Deviation 0.71
Waitlist Control GroupMood State: VigourChange of vigour in post-control condition-0.68 score on a scaleStandard Deviation 0.64
Waitlist Control GroupMood State: VigourChange of vigour in pre-control condition-0.85 score on a scaleStandard Deviation 0.66
Waitlist Control GroupMood State: VigourChange of vigour in pre-mental fatigue condition-1.05 score on a scaleStandard Deviation 0.92
Waitlist Control GroupMood State: VigourChange of vigour in post-mental fatigue condition-0.71 score on a scaleStandard Deviation 0.72
p-value: >0.05ANCOVA
Secondary

Objective Mental Fatigue

Both at baseline and post-intervention, participants completed either a 30-min 100% incongruent version Stroop task (i.e., mental fatigue condition) or a 30-min 100% congruent version Stroop task (i.e., control condition). In the Stroop task, accuracy (ACC) was calculated as an index of objective mental fatigue. It is expressed as a percentage, determined by dividing the number of correct responses by the total number of responses.

Time frame: Post 30-minute mental fatigue and control condition at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 1 in post-test (mental fatigue condition)87.25 percentageStandard Deviation 8.13
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 5 in pre-test (mental fatigue condition)82.94 percentageStandard Deviation 16.29
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 2 in post-test (mental fatigue condition)84.69 percentageStandard Deviation 9.87
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 1 in pre-test (mental fatigue condition)87.09 percentageStandard Deviation 9.82
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 3 in post-test (mental fatigue condition)83.20 percentageStandard Deviation 11.14
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 1 in pre-test (control condition)91.65 percentageStandard Deviation 6.1
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 4 in post-test (mental fatigue condition)83.70 percentageStandard Deviation 10.92
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 2 in pre-test (control condition)89.61 percentageStandard Deviation 8.53
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 5 in post-test (mental fatigue condition)82.06 percentageStandard Deviation 13.29
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 3 in pre-test (mental fatigue condition)82.54 percentageStandard Deviation 13.8
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 1 in post-test (control condition)93.21 percentageStandard Deviation 5.47
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 3 in pre-test (control condition)86.92 percentageStandard Deviation 12.89
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 2 in post-test (control condition)90.84 percentageStandard Deviation 7.28
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 4 in pre-test (control condition)87.94 percentageStandard Deviation 8.77
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 3 in post-test (control condition)90.85 percentageStandard Deviation 6.14
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 4 in pre-test (mental fatigue condition)83.72 percentageStandard Deviation 13.3
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 4 in post-test (control condition)88.81 percentageStandard Deviation 7.19
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 5 in pre-test (control condition)86.70 percentageStandard Deviation 10.68
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 5 in post-test (control condition)87.41 percentageStandard Deviation 8.48
Mindfulness Training GroupObjective Mental FatigueThe ACC of Stroop_Block 2 in pre-test (mental fatigue condition)83.77 percentageStandard Deviation 1.43
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 5 in post-test (control condition)88.68 percentageStandard Deviation 8.09
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 1 in pre-test (mental fatigue condition)88.11 percentageStandard Deviation 8.92
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 2 in pre-test (mental fatigue condition)85.27 percentageStandard Deviation 12.18
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 3 in pre-test (mental fatigue condition)86.36 percentageStandard Deviation 11.12
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 4 in pre-test (mental fatigue condition)85.36 percentageStandard Deviation 11.24
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 5 in pre-test (mental fatigue condition)82.63 percentageStandard Deviation 17.43
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 2 in pre-test (control condition)91.52 percentageStandard Deviation 5.47
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 3 in pre-test (control condition)90.68 percentageStandard Deviation 7.03
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 4 in pre-test (control condition)88.96 percentageStandard Deviation 9.9
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 5 in pre-test (control condition)85.62 percentageStandard Deviation 11.96
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 1 in post-test (mental fatigue condition)87.77 percentageStandard Deviation 10.21
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 2 in post-test (mental fatigue condition)85.93 percentageStandard Deviation 9.81
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 3 in post-test (mental fatigue condition)84.73 percentageStandard Deviation 11.75
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 4 in post-test (mental fatigue condition)84.41 percentageStandard Deviation 10.04
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 5 in post-test (mental fatigue condition)84.24 percentageStandard Deviation 10.86
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 1 in post-test (control condition)94.35 percentageStandard Deviation 4.42
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 2 in post-test (control condition)91.59 percentageStandard Deviation 5.93
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 3 in post-test (control condition)91.97 percentageStandard Deviation 6.27
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 4 in post-test (control condition)90.08 percentageStandard Deviation 5.86
Waitlist Control GroupObjective Mental FatigueThe ACC of Stroop_Block 1 in pre-test (control condition)92.63 percentageStandard Deviation 5.83
p-value: <0.01ANOVA
Secondary

Perception of Effort

During the graded exercise test, the perception of effort will be asked at beginning and every 2.5-min using Borg 6 to 20 scale, until the participant comes to voluntary exhaustion.

Time frame: every 2.5 minutes during graded exercise test

Secondary

Subjective Mental Fatigue

Both in the baseline and post-intervention, the visual analog scale for mental fatigue (VAS-MF) was used to assess changes in subjective mental fatigue before and after experimental manipulation. The scale ranges from 0 (not at all mentally fatigued) to 100 (extremely mentally fatigued).

Time frame: Before, after 30-minute Stroop task and after Flanker task in the mental fatigue and control condition at pre-test and post-test (8 weeks)

ArmMeasureGroupValue (MEAN)Dispersion
Mindfulness Training GroupSubjective Mental FatigueVAS score at T2 in pre-test (mental fatigue condition)47.69 score on a scaleStandard Deviation 13.66
Mindfulness Training GroupSubjective Mental FatigueVAS score at T1 in post-test (mental fatigue condition)22.38 score on a scaleStandard Deviation 13.43
Mindfulness Training GroupSubjective Mental FatigueVAS score at T1 in pre-test (control condition)24.81 score on a scaleStandard Deviation 13.38
Mindfulness Training GroupSubjective Mental FatigueVAS score at T2 in post-test (mental fatigue condition)48.50 score on a scaleStandard Deviation 13.79
Mindfulness Training GroupSubjective Mental FatigueVAS score at T1 in pre-test (mental fatigue condition)25.19 score on a scaleStandard Deviation 11.44
Mindfulness Training GroupSubjective Mental FatigueVAS score at T3 in post-test (mental fatigue condition)50.77 score on a scaleStandard Deviation 15.56
Mindfulness Training GroupSubjective Mental FatigueVAS score at T2 in pre-test (control condition)36.92 score on a scaleStandard Deviation 16
Mindfulness Training GroupSubjective Mental FatigueVAS score at T1 in post-test (control condition)21.08 score on a scaleStandard Deviation 12.94
Mindfulness Training GroupSubjective Mental FatigueVAS score at T3 in pre-test (mental fatigue condition)57.12 score on a scaleStandard Deviation 16.01
Mindfulness Training GroupSubjective Mental FatigueVAS score at T2 in post-test (control condition)36.69 score on a scaleStandard Deviation 13.49
Mindfulness Training GroupSubjective Mental FatigueVAS score at T3 in pre-test (control condition)40.77 score on a scaleStandard Deviation 16.89
Mindfulness Training GroupSubjective Mental FatigueVAS score at T3 in post-test (control condition)35.08 score on a scaleStandard Deviation 10.62
Waitlist Control GroupSubjective Mental FatigueVAS score at T3 in post-test (control condition)42.07 score on a scaleStandard Deviation 12.43
Waitlist Control GroupSubjective Mental FatigueVAS score at T1 in pre-test (mental fatigue condition)24.26 score on a scaleStandard Deviation 10.89
Waitlist Control GroupSubjective Mental FatigueVAS score at T2 in pre-test (mental fatigue condition)49.07 score on a scaleStandard Deviation 16.06
Waitlist Control GroupSubjective Mental FatigueVAS score at T3 in pre-test (mental fatigue condition)55.56 score on a scaleStandard Deviation 22.67
Waitlist Control GroupSubjective Mental FatigueVAS score at T1 in pre-test (control condition)21.30 score on a scaleStandard Deviation 11.4
Waitlist Control GroupSubjective Mental FatigueVAS score at T2 in pre-test (control condition)39.26 score on a scaleStandard Deviation 11.49
Waitlist Control GroupSubjective Mental FatigueVAS score at T3 in pre-test (control condition)40.19 score on a scaleStandard Deviation 13.9
Waitlist Control GroupSubjective Mental FatigueVAS score at T1 in post-test (mental fatigue condition)22.78 score on a scaleStandard Deviation 11.06
Waitlist Control GroupSubjective Mental FatigueVAS score at T2 in post-test (mental fatigue condition)50.52 score on a scaleStandard Deviation 18.09
Waitlist Control GroupSubjective Mental FatigueVAS score at T3 in post-test (mental fatigue condition)50.78 score on a scaleStandard Deviation 18.27
Waitlist Control GroupSubjective Mental FatigueVAS score at T1 in post-test (control condition)24.04 score on a scaleStandard Deviation 15.63
Waitlist Control GroupSubjective Mental FatigueVAS score at T2 in post-test (control condition)42.04 score on a scaleStandard Deviation 14.27
p-value: <0.01ANOVA

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026