Aneurysmal Rupture
Conditions
Keywords
Signal intensity gradient, Wall shear stress, Aneurysmal rupture, Time-of-Flight MRI
Brief summary
10-20% of patients with subarachnoid hemorrhage die before they arrive at the hospital, and about 25% die within 24 hours. About 1% of patients are diagnosed with cerebral aneurysms in imaging tests for health checkups, and many of them experience aneurysmal rupture during their lifetime, so it is not a rare disease. Wall shear stress is known to be a factor that reflects the state of blood vessels, and particularly plays an important role in the patency of the intima of blood vessels. In the meantime, computed fluid dynamics (CFD), a representative method for calculating wall shear stress, assumes a virtual rigid pipe and applies a preset value. This does not accurately reflect the physiological and dynamic state of the actual blood vessel. The investigators intend to measure the patient's wall shear stress using the SIG of the MRA-TOF technique, which reflects the physiological characteristics of individual patients, and to analyze the association with rupture of the intracranial aneurysm.
Interventions
DIAGNOSTIC_TESTSignal intensity gradient
In time-of-flight (TOF) MRA, The signal intensities at the iso-point (Φa; signal intensity at position A \[Xa\] along the arterial contour line) and at the inner point (Φb; signal intensity at position B \[Xb\]) were calculated by using a trilinear interpolation algorithm based on the positions and signal intensities in the eight neighboring voxels. The signal intensities of TOF-MRA were normalized to eliminate the offset and scale effects across the MRA datasets of participants. For each iso-point (position A), the SIG was calculated from the difference in signal intensities between points A and B as follows: Scalar SIG, SI/mm = (Φb - Φa) / │Xb - Xa│ (1) Vector SIG, SI/mm = (Φb - Φa) n / │Xb - Xa│ (2)
Sponsors
Chonbuk National University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\<Ruptured group\> Inclusion Criteria: 1\) Patients over 18 years of age who visited our hospital for acute subarachnoid hemorrhage due to rupture of a intracranial aneurysm (2) Among patients satisfying (1), who had intracranial magnetic resonance imaging (time-of-flight (TOF) technique applied; diffusion-weighted imaging, including apparent diffusion coefficient) before subarachnoid hemorrhage occurred.
Exclusion criteria
1. Patients under the age of 18 2. Patients with subarachnoid hemorrhage due to causes other than rupture of intracranial aneurysm 3. Patients with poor imaging quality due to artifacts caused by patient movement during brain magnetic resonance imaging examination \<Unruptured group\> Inclusion Criteria: 1. Magnetic resonance imaging performed during the screening period (Time-of-Flight (TOF) technique is applied to intracranial vessel imaging; It also includes diffusion-weighted imaging and apparent diffusion coefficient) 2. Patients diagnosed with unruptured intracranial aneurysm in the final reading of brain MR test 3. Patients who remain without aneurysmal rupture on follow-up intracranial magnetic resonance imaging
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Degree of signal intensity gradient in aneurysmal sac | Average 4-6 years | The investigators will measure the degree of signal intensity gradient (SIG) from brain TOF-MRA in aneurysmal sac. The measured SIG in ruptured group would be lower than that in unruptured group. |
Countries
South Korea
Contacts
Primary ContactChan-Hyuk Lee, Dr.
Outcome results
None listed