Ankylosing Spondylitis
Conditions
Keywords
Ankylosing Spondylitis, Disease activity, Inflammatory marker
Brief summary
Axial spondyloarthritis is an inflammatory disease characterized by the involvement of the sacroiliac joints and the spine. Disease activity and structural changes are determined by using physical examination, imaging studies, laboratory parameters, and patient-reported indices. Among laboratory studies, Erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) are the most commonly utilized parameters. However, the level of ESR and CRP are inadequate in demonstrating disease activity and inflammation compared to other diseases. In this study, the investigators aimed to analyze and compare the systemic inflammatory index (SII), which is a hematologic parameter between subjects with radiographic axial spondyloarthritis, non-radiographic axial spondyloarthritis, and healthy controls. Secondarily, the relationship between disease activity and enthesitis score and SII scores in patients with radiographic and non-radiographic axial spondyloarthritis will be investigated.
Detailed description
Axial spondyloarthritis is an inflammatory disease characterized by the involvement of the sacroiliac joints and the spine. Disease activity and structural changes are determined by using physical examination, imaging studies, laboratory parameters, and patient-reported indices. Among laboratory studies, Erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) are the most commonly utilized parameters. ESR and CRP are within the normal range in 40-50% of patients with spondyloarthritis and may remain within the normal range even during active disease. Therefore, the use of biomarkers suitable for the pathophysiology of the disease have been recommended. However, these tests are difficult to access and there is no consensus on showing disease activity. Systemic inflammatory index (SII) is a novel hematologic parameter and previous studies reported the relationship with disease activity in rheumatologic diseases, but the results are inconsistent. This study will compare the SII between subjects with radiographic and non-radiographic axial spondyloarthritis with healthy subjects. Secondly, the study will investigate the relationship between SII, a new inflammation parameter, and disease activity in patients diagnosed with radiographic and non-radiographic axial spondyloarthritis.
Interventions
OTHERSystemic inflammatory index
neutrophil count x platelet count/lymphocyte count
OTHERBASDAI
Bath Ankylosing Spondylitis Disease Activity Index includes six questions which includes the following six parameters: fatigue, spinal pain, peripheral joint pain, attachment point inflammation, and duration and severity of morning stiffness. A total score, ranging from 0 to 10, was calculated according to the patients' responses to six questions, with a higher score indicating more severe illness.
OTHERASDAS-ESR
The ASDAS-ESR is deduced using formula that is chosen by the ASAS group. ASDAS-ESR is calculated with the answers of spinal, peripheral pain, morning stiffness on BASDAI, the patient global assessment, and erythrocyte sedimentation rate (mm/h).
OTHERASDAS-CRP
The ASDAS-CRP is deduced using formula that is chosen by the ASAS group. ASDAS-CRP is calculated with the answers of spinal, peripheral pain, morning stiffness on BASDAI, the patient global assessment, and erythrocyte C-reactive protein (mg/dl).
OTHERMASES
It is used to evaluate the sensitivity of enthesis points by palpation in patients with ankylosing spondylitis. Scoring is done by giving 1 point for sensitive areas and 0 points if there is no sensitivity on the fifth lumbar spinous process, bilateral first and seventh costochondral joints, iliac crystals, posterior and anterior iliac spines, attachment sites of achilles tendon to the calcaneus.
Sponsors
Bozyaka Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Diagnosed with axial spondyloarthritis according to the ASAS classification criteria
Exclusion criteria
* Acute/chronic infections * Presence of other autoimmune diseases * Diabetes mellitus * Coronary arterial disease * Hypertension * Malignancy * Hematological diseases * Liver diseases * Pregnancy/Lactation * Renal diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systemic inflammatory index | Baseline | neutrophils \* platelets/lymphocytes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) | Baseline | The overall BASDAI score ranges from 0 to 10. Lower scores indicate less disease activity. |
| Ankylosing Spondylitis Disease Activity Score (ASDAS)-ESR | Baseline | \<1.3 between inactive disease and low disease activity, \<2.1 between moderate disease activity and high disease activity, and \>3.5 between high disease activity and very high disease activity. |
| Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP | Baseline | \<1.3 between inactive disease and low disease activity, \<2.1 between moderate disease activity and high disease activity, and \>3.5 between high disease activity and very high disease activity. |
| Maastricht Ankylosing Spondylitis Entheses Score (MASES) | Baseline | Maastricht Ankylosing Spondylitis Entheses Score MASES ranging from 0 (0 sites with tenderness) to 13 (worst possible score; 13 sites with tenderness). Negative values indicate better outcome. |
Countries
Turkey (Türkiye)
Outcome results
None listed