Pediatric ALL
Conditions
Brief summary
In pediatric patients in the prone position, the reliability of pulse pressure variation and stroke volume variation, and pleth variability index to predict fluid responsiveness have not previously been established. Perioperatively, in this setting, optimizing fluid management can be challenging, and fluid overload is associated with both intraoperative and postoperative complications. The investigator designed this study to assess the sensitivity and specificity of baseline PPV, SVV, and PVI the tidal volume (VT) challenge (VTC) and in predicting fluid responsiveness during elective neurosurgery.
Interventions
PROCEDURETVC
Tidal volume challenge from 6ml/kg to 10ml/kg for 1 min.
Sponsors
Seoul National University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 6 Years
Healthy volunteers
No
Inclusion criteria
* elective neurosurgery and requiring prone positioning
Exclusion criteria
* (1) chronic cardiac arrhythmia; (2) depressed left (\<30% of ejection fraction) (3) patients with pulmonary disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fluid responsiveness prediction using AUC of ROC curve analysis | from induction of anesthesia to end of operation, about 5 hours | stroke volume index increase more than 10% from baseline after volume administration (10ml/kg) Fluid responsiveness parameters; PPV, SVV, PVI, rPVI before and after tidal volume challenge |
Countries
South Korea
Outcome results
None listed