Sepsis
Conditions
Keywords
Eletroencephalography, Sepsis, Septic shock, Critical care, cognitive dysfunction, Montreal cognitive assessment
Brief summary
The investigators evaluated the electroencephalographic pattern by the Sinek and Young scales during ICU stay and its correlation with cognitive impairment determined by the Montreal Cognitive Assessment (MOCA) in septic patients after 3 months of ICU discharge..
Detailed description
The investigators prospectively evaluate patients with sepsis and septic shock expected to stay in the intensive care unit (ICU) for at least 4 days. We used Sinek and Young scales to classify electroencephalographic patterns during ICU stay (in the first 24 hours after admission and in the third ICU day) and correlate with cognitive outcome evaluated with MOCA score 3 months after ICU discharge. The investigators evaluate as primary outcome the association between electroencephalographic abnormalities and cognitive dysfunction measured by the Montreal Cognitive Assessment (MoCA) 3 months after ICU discharge and secondary outcomes as association between electroencephalographic patterns and 28 days mortality, Quality of Life (SF-36) after 3 months of discharge, ventilator free days, vasoactive drug free days and Glasgow outcome scale.
Interventions
DIAGNOSTIC_TESTEletroencephalography
We used Sinek and Young Scale to classify electroencephalographic patterns and cognitive outcome with MOCA score.
Sponsors
Hospital Sao Domingos
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Included were patients aged above 18 years, who were expected to stay in the ICU for at least 4 days, between November 2021 and November 2022. \-
Exclusion criteria
* CNS infections, * Structural abnormalities of the CNS, known * Liver or uremic encephalopathy, * Advanced dementia (Mini mental \< 9), * Psychiatric disorder * Epilepsy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Electroencephalographic patterns | 3 months after hospital discharge | Electroencephalographic patterns determined by Sinek and Young scales. The Synek outcome Scale ranges from normal (alpha dominant rhythm) to suppression (worst outcome). The scale assesses the outcome of patients with sepsis. Young's Scale Electroencephalographic classification of coma assesses outcome of patients with sepsis Outcome varies from normal (Delta/Theta Rhythm \> 50% of record). worst result Suppression The two scales are complementary. |
| Cognitive evaluation | 3 months after hospital discharge | Cognitive dysfunction measured by Montreal Cognitive Assessment (MoCA) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| electroencephalographic patterns and 28 days mortality . | 28 days | Electroencephalographic patterns determined by Sinel and Young scales and 28 days .mortality. The Synek outcome Scale ranges from normal (alpha dominant rhythm) to suppression (worst outcome). The scale assesses the outcome of patients with sepsis. Young's Scale Electroencephalographic classification of coma assesses outcome of patients with sepsis Outcome varies from normal (Delta/Theta Rhythm \> 50% of record). worst result Suppression The two scales are complementary. |
| Quality of Life (SF-36) after 3 months of discharge | 3 months after hospital discharge | Quality of life determined through Short-Form Health Survey (SF-36). Scores range from 0 to 100, 0 indicating the less favorable health status and 100 the most favorable one. |
Countries
Brazil
Outcome results
None listed