Postoperative Lactate and Atrial Fibrillation After CABG

Association of Postoperative Lactate Levels With Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Graft Surgery

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05448521

Enrollment

250

Registered

2022-07-07

Start date

2022-08-15

Completion date

2023-09-15

Last updated

2022-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Coronary Artery Disease

Brief summary

Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG). It has been estimated that 5-40% of CABG patients experience POAF. Advanced age, P wave abnormalities, left atrial dilation, emergency surgery, low left ventricle ejection fraction, low glomerular filtration rate and chronic obstructive pulmonary disease have been reported in the etiology. Predicting which patients would experience POAF following CABG is important since it would allow physicians to apply more focused prophylactic measures. Lactate is the final product of anaerobic glycolysis. Serum lactate level are increased in case of inadequate oxygen delivery to tissues. The investigators aim to assess whether serum lactate levels measured early in the postoperative period could be used as a predictive marker of POAF in adults undergoing isolated CABG.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Undergoing isolated CABG * Age \>18 years

Exclusion criteria

* Age \<18 years * Pregnancy * History of paroxysmal atrial fibrillation prior to surgery * Undergoing concomitant procedures (e.g., CABG + valve surgery) * Any preoperative cardiac rhythm other than normal sinus rhythm * More than mild cardiac valve stenosis or insufficiency

Design outcomes

Primary

Measure	Time frame	Description
Postoperative atrial fibrillation	30 days	New-onset atrial fibrillation occurring in the immediate period after CABG

Countries

Turkey (Türkiye)

Contacts

Primary ContactZeki Temizturk, MD

zekitmztrk5806@gmail.com902129096000

Backup ContactAhmet Can Topcu, MD

ahmet.topcu@icloud.com902165001500

Outcome results