Cerebral Vein Thrombosis, Cerebral Venous Sinus Thrombosis
Conditions
Keywords
Cerebral Venous Sinus Thrombosis
Brief summary
This study will investigate the epidemiology, risk factors, diagnostics, treatment, and the long-term prognosis of cerebral venous thrombosis in China.
Detailed description
The epidemiology, risk factors, diagnosis and treatment of Cerebral Venous Thrombosis (CVT) in China are still unclear. A retrospective hospital-based study will be conducted at fifty different hospitals across 31 provinces in China. This study will use ICD-10 to search patients diagnosed with CVT between January 1, 2018 and June 15, 2022 across 31 provinces and municipalities of 104 hospitals in China. Risk factors, clinical and radiological findings, treatment and short-term outcomes will be recorded from the hospital record system. Finally, a prospective follow-up will be conducted for all of the patients enrolled above. By combining data collected from retrospective hospital records with the new follow-up, it will be possible to better understand the epidemiology, risk factors, diagnosis, treatment and the long-term prognosis of CVT in China.
Interventions
None listed
Sponsors
Brain Hospital of Hunan Provincial
The First Affiliated Hospital of Zhengzhou University
The Affiliated Hospital of Xuzhou Medical University
Guizhou Provincial People's Hospital
Capital Medical University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis diagnosed by digital subtraction angiography (DSA), magnetic resonance venography (MRV), computed tomography venography (CTV) or high-resolution magnetic resonance imaging (HR-MRI).
Exclusion criteria
* None of the patient, trustee or immediate family members signed the informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Favorable clinical outcome (modified Rankin score 0-1) | Baseline to three years | — |
| All-cause mortality | Baseline to three years | A combination of death form of all causes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Headache after CVT | Baseline to three years | Headache Impact Test - 6 score |
| Incidence of hemorrhagic complication | Baseline to three years | Extracranial hemorrhage (fall in hemoglobin of 2 gram/dl or more within 48 hours) or intracranial hemorrhage |
| Recanalization rate of cerebral venous system | Baseline to three years | — |
| Recurrence of cerebral venous thrombosis | Baseline to three years | Diagnosed by DSA, MRV, CTV or HR-MRI |
| Incidence of acute ischemic stroke | Baseline to three years | — |
| Incidence of pulmonary embolism | Baseline to three years | — |
| Psychological distress after CVT | Baseline to three years | Population Health Questionnaire (PHQ)-9 score |
| Incidence of epilepsy | Baseline to three years | — |
| Favorable clinical outcome (modified Rankin score 0-2) | Baseline to three years | — |
Countries
China
Outcome results
None listed