Primary Aldosteronism, Adrenal Cushing Syndrome, Pheochromocytoma, Endocrine Neoplasia
Conditions
Brief summary
Sudden Cardiac Death is a leading cause of mortality and remains a major public health burden worldwide. Cardiac arrest due to coronary heart disease explains a large proportion of the cases, but if autopsy is not performed the exact underlying cause remains obscure in many adults who face sudden death outside heath care organizations. The investigators aim to find proof that primary aldosteronism is a risk factor for sudden death and to characterize the prevalence of adrenal pathology in sudden death of undetermined cause in a case-control study. In addition, the study aims to characterize the prevalence of other adrenal pathology i.e. silent adenomas, cortisol-producing adenomas and pheochromocytomas in sudden death. The investigators also seek evidence that other endocrine hormone overproduction-causing diseases are more prevalent in persons with sudden death compared with those experiencing traumatic or suicidal death sudden death.
Interventions
DIAGNOSTIC_TESTAdrenal aldosterone synthase (CYP11B2) staining
Immunoshistochemical diagnosis of primary aldosteronism
DIAGNOSTIC_TESTAdrenal cortisol synthase (CYP11B1) staining
Immunoshistochemical diagnosis of adrenal hypercortisolism
DIAGNOSTIC_TESTHistopathological analysis
Diagnosis of any endocrine neoplasia other than primary aldosteronism or adrenal hypercortisolism
Sponsors
Finnish Institute for Health and Welfare
University of Helsinki
Tampere University Hospital
Tampere University
Helsinki University Central Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
35 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Consecutive patients with out-of-hospital, sudden death
Exclusion criteria
1. Estimated time from death to refrigerator more than 24-48 hours and in the refrigerator time more than 7 days (susceptibility to excessive tissue breakdown) 2. Terminal disease 3. Institutionalized patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CYP11B2 staining in adrenal glands | Through study completion, an average of 2 years | Histopathological diagnosis of the autopsy |
| CYP11B1 staining in adrenal glands | Through study completion, an average of 2 years | Histopathological diagnosis of the autopsy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CYP11B2 staining in adrenal glands | Through study completion, an average of 2 years | Histopathological diagnosis of the autopsy |
| Pheochromocytoma or paraganglioma | Through study completion, an average of 2 years | Histopathological diagnosis of the autopsy |
| Neuroendocrine tumor | Through study completion, an average of 2 years | Histopathological diagnosis of the autopsy |
Countries
Finland
Outcome results
None listed