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Quadratus Lumborum Block vs Erector Spinal Block for Post Abdomen Surgery Analgesia

Quadratus Lumborum Block Versus Erector Spinal Block - Comparison of the Effectiveness of the Analgesic Effect in Patients After Abdominal Surgery

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05446727
Enrollment
100
Registered
2022-07-07
Start date
2022-05-01
Completion date
2023-12-31
Last updated
2025-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthetics, Local, Pain, Acute, Postoperative Pain

Keywords

Anesthetics, Local Anesthetics

Brief summary

Prior to surgery, patients will be stratified into groups according to the type of surgical procedure. The anticipated groups are as follows: Patients with colorectal cancer Patients with prostate cancer Patients with renal cancer Patients undergoing surgery for gallbladder cholelithiasis. The Erector Spinal Block (ESP) is based on the deposition of the local anesthetic in the inter-fascial space between the dorsal extensor muscle and the intercostal muscles at the height of the transverse processes. The scope of the blockade covers the dorsal and ventral branches of the thoracic spinal nerves, but also in most cases the investigetors are able to obtain a wide distribution of the drug into the paravertebral space by permeating the local anesthetic through the fascial compartments. The clinical effect of the blockade is due to blocking the nerve structures of the paravertebral space (spinal nerve branches and the sympathetic trunk). The scope of the blockade, after its execution at the level of Th5, most often includes the segments from Th1 to L1. Currently, the Quadratus Lumborum block (QL block) is performed as one of the perioperative pain management procedures for all generations (pediatrics, pregnant, and adult) undergoing abdominal surgery. The local anesthetic injected via the approach of the anterior QL block ( QL1 block ) can more easily extend beyond the TAP to the thoracic paravertebral space or the thoracolumbar plane, the posterior QL block entails a broader sensory-level analgesic and may generate analgesia from T7 to L1.

Detailed description

In abdomen surgery, overall pain is a conglomerate of three different and clinically separate components: incisional pain (somatic pain), visceral pain (deep intra abdominal pain), and shoulder pain due to peritoneal stretching and diaphragmatic irritation associated with carbon dioxide insufflation. Moreover, it has been hypothesized that intense acute pain after labdomen surgery may predict development of chronic pain. Without effective treatment, this ongoing pain may delay recovery, mandate inpatient admission, and thereby increase the cost of such care.

Interventions

DRUGRopivacaine injection

30ml of 0.35% ropivacaine bilaterally

Sponsors

Jagiellonian University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)

Masking description

Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* Patients requiring abdomen surgery * Patients of age 18 and over * BMI \< 40 * Patients who are expected to stay in-hospital overnight after surgery

Exclusion criteria

* Patient refusal * Contraindications to paravertebral blocks: Infection at the site of needle insertion, empyema, allergy to local anesthetic drugs, and tumor occupying the thoracic paravertebral space, coagulopathy, bleeding disorder or therapeutic anticoagulation * Known allergy to local anesthetics * Inability to provide informed consent * Inability to use a PCA due to languate or comprehension barriers * BMI \>= 40 * Any patient on opioids for greater than or equal to 3 months duration prior to surgery * Patients with chronic pain syndromes

Design outcomes

Primary

MeasureTime frameDescription
Total long acting opioid consumption in oxycodone equivalents1 daysthe total dosage of given drug

Secondary

MeasureTime frameDescription
Pain scores will be recorded at intervals. The Numerical Rating Scale (NRS) is an 11-point scale where 0 is no pain and 10 is the worst pain imaginable.1 daysThe patients will be asked about level of pain every 2 hours
Incidence of postoperative nausea-vomiting; itching; local anesthetic toxicity;1vdaysThe patients will be asked about Incidence of postoperative nausea-vomiting; itching; local anesthetic toxicity.

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026